奥氮平与阿立哌唑治疗精神分裂症对照研究  

A comparative study of olanzapine and aripiprazole in treatment of schizophrenia

作　　者：苏琴[1] 黄惠容[1] 高爱群[1] 黄东[1] 

机构地区：[1]福建闽清精神病防治院,350800

出　　处：《临床精神医学杂志》2008年第6期409-410,共2页Journal of Clinical Psychiatry

摘　　要：目的:比较奥氮平与阿立哌唑治疗精神分裂症的疗效与安全性。方法:100例精神分裂症患者随机分为两组,每组各50例。分别给予奥氮平和阿立哌唑治疗,疗程8周。采用阳性与阴性症状量表(PANSS)、临床疗效总评量表疾病严重程度(CGI-SI)、治疗中出现的症状量表(TESS)评定疗效及不良反应。结果:两组PANSS总分及CGI-SI评分均较治疗前显著下降(P均<0.01)。奥氮平组显效率76.0%,阿立哌唑组显效率72.0%,两组疗效相仿(P>0.05)。奥氮平组嗜睡、体质量增加、血脂升高的不良反应均明显高于阿立哌唑组(P<0.01);阿立哌唑组锥体外系反应、失眠、兴奋或激越均明显高于奥氮平组(P<0.01)。结论:奥氮平和阿立哌唑对精神分裂症的疗效相当,安全性较高。Objective： To compare the efficacy and safety of olanzapine and aripiprazole in the treatment of schizophrenia. Method：100 patients were randomly assigned to olanzapine group or aripiprazole group respectively for 8 weeks. The positive and negative symptom scale （PANSS） and clinical global impressions-severity of illness rating scale （ CGI-SI ） were used to measure the efficacy; the treatment emergent symptom scale （TESS） was used to measure side effects. Results：Marked improvement rate of olanzapine group was 76. 0% ,and aripiprazole group was 72.0% , the efficacy was similar in two groups （P 〉 0.05 ） ;side effects of olanzapine were drowsiness, increase of body weight and blood pressure, which were obviously more frequent than in aripiprazole （P 〈0.01 ） ;the main side effects of aripiprazole were extrapyramidal side effects and insomnia or excitement,which were more frequent than those in olanzapine group （P 〈 0.01 ）. Conclusion： Olanzapine had similar effects to aripiprazole in the treatment of schizophrenia. They have high safety.

关 键 词：精神分裂症 奥氮平 阿立哌唑 

分 类 号：R749.3[医药卫生—神经病学与精神病学]