胰岛素与阿尔茨海默病  

Insulin and Alzheimer's disease

作　　者：崔佩菁[1] 陈生弟[2] 

机构地区：[1]上海交通大学医学院瑞金医院老年科,上海200025 [2]上海交通大学医学院瑞金医院神经科上海阿尔茨海默病中心,上海200025

出　　处：《上海交通大学学报（医学版）》2008年第12期1587-1589,共3页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：近年来,阿尔茨海默病(AD)的发病率呈明显增加的趋势,但其发病机制仍不明确。胰岛素及其受体被认为可能与AD的发病有关。文章就胰岛素与脑内葡萄糖代谢的关系以及胰岛素、胰岛素受体和胰岛素抵抗与AD发病的关系及其可能机制进行综述,并介绍AD的治疗进展。Recently, the incidence of Alzheimer＇s disease has been significantly increasing. However, the pathogenesis of Alzheimer＇s disease remains unknown. It is presumed that insulin and insulin receptor may be involved in the pathogenesis of Alzheimer＇s disease. The relationship between insulin and cerebral glucose metabolism, the relationship between insulin, insulin receptor, insulin resistance and pathogenesis of Alzheimer＇s disease as well as the possible mechanism are reviewed in this paper, and the progress of treatment of AD is also described.

关 键 词：胰岛素 阿尔茨海默病 发病机制 

分 类 号：R749.16[医药卫生—神经病学与精神病学]