肝硬化腹水患者并发自发性细菌性腹膜炎的危险因素分析  

Risk factors for spontaneous bacterial peritonitis in cirrhotic patients with ascites

作　　者：刘跃进[1] 王桂玲[1] 王炜[2] 

机构地区：[1]济南市传染病医院院内感染科,济南250021 [2]山东大学附属省立医院院内感染科,济南250021

出　　处：《山东大学学报（医学版）》2008年第12期1166-1168,共3页Journal of Shandong University:Health Sciences

摘　　要：目的探讨肝硬化腹水患者并发自发性细菌性腹膜炎(SBP)的危险因素。方法将住院治疗的193例肝硬化腹水患者分为SBP组和非SBP组,从血清白蛋白、血清胆红素、血小板,凝血酶原时间国际标准化比值(INR)、腹水持续时间,是否合并肝癌、糖尿病、肝性脑病、上消化道出血,饮酒及年龄、性别、肝硬化病因等方面,分别采用单变量(t检验或χ2检验)及多变量(Logistic回归)方法进行对比分析。结果SBP的发生率为30.4%(45/193);单变量分析显示SBP组与非SBP组之间在合并肝癌百分比、血清白蛋白及饮酒3个方面差异具有显著性;Logistic回归显示只有血清白蛋白及饮酒两个因素入选回归模型(P<0.05)。结论较低的血清白蛋白及饮酒二者可能是肝硬化腹水患者并发SBP的独立高危因素。Objective To investigate the risk factors for spontaneous bacterial peritonitis （SBP） in cirrhotic patients with ascites. Methods 193 cirrhotic patients with ascites, who were divided into two groups, the one with SBP and the other without SBP, were included in this study. The following factors such as serum albumin, serum biliruhin, platelet count, international normalized ratio, duration of ascites complicated with or without hepatoeellular carcinoma, diabetes mellitus, hepatic encephalopathy, upper gastrointestinal hemorrhage , alcohol consumption, sex, age and cause of cirrhosis were analyzed. Results Prevalence of SBP was 30.4% （45/193）. Univariate analysis revealed significant differences between the two groups with regard to serum albumin, aseites complicated with or without hepatocellular carcinoma and alcohol consumption. On the logistic regression analysis, serum albumin level and alcohol consumption were selected as significant independent factors contributing to the development of SBP（ P 〈 0.05）. Conclusion Low serum albumin and alcohol consumption are independently high risk factors for SBP.

关 键 词：肝硬化 腹膜炎 危险因素 

分 类 号：R575.2[医药卫生—消化系统]