国产利培酮治疗精神分裂症的开放性研究  

Open clinical study of risperidone in treatment of schizophrenia

作　　者：宁洁[1] 

机构地区：[1]重庆市精神卫生中心,401147

出　　处：《重庆医学》2008年第24期2818-2819,共2页Chongqing medicine

摘　　要：目的评价国产利培酮(利培酮胶囊)的疗效及安全性。方法对30例精神分裂症患者给予利培酮胶囊治疗6周,平均治疗剂量为(4.27±1.03)mg/d,采用简明精神疾病量表(BPRS)、药物治疗不良反应量表(TESS)分别评定疗效及不良反应。结果利培酮胶囊具有良好的疗效,总有效率为86.7%,显效率为53.3%,出现的不良反应主要为锥体外系反应、失眠、心动过速等。结论利培酮胶囊对精神分裂症患者疗效较好,安全性好,不良反应少。Objective To observe the effect and safety of risperidone capsule in the treatment of schizophrenia. Methods Thirty schizophrenia patients were treated with risperidone capsule for 6 weeks. The average therapeutic dose was （4.27 ± 1.03）mg/d. BPRS was used to evaluate the therapeutic effect and TESS was used to evaluate the drug side effects. Results Risperidone capsule had satisfactory effect on schizophrenia, 86. 7% of the patients were improved, in which 53.3% improved. The main side effects were EPS,insomina and taehycardia. Conclusion Risp＇eridone capsule can effectively improve the symptoms of the patients with schizophrenia,the side effects are mild,the safety of this product is good.

关 键 词：国产利培酮 精神分裂症 疗效 安全性 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R971.41[医药卫生—临床医学]