Rink Amide树脂结构对多肽合成的影响研究  

THE INFLUENCE OF THE STRUCTURE OF RINK AMIDE RESIN TO PEPTIDE SYNTHESIS

作　　者：郑彦慧[1] 张艳平[1] 张浩[1] 马玉新[1,2] 路延龄[1,2] 史作清[1,2] 

机构地区：[1]天津南开和成科技有限公司,天津300071 [2]南开大学化学学院,天津300071

出　　处：《离子交换与吸附》2008年第6期563-569,共7页Ion Exchange and Adsorption

摘　　要：研究了Rink Amide树脂取代度、溶胀度及肽链的长度不同对肽合成收率的影响,并对影响Rink Amide树脂溶胀度的因素进行了研究,结果表明,合成长肽时低取代度、高溶胀度的Rink Amide树脂能获得较好的肽收率。The influence to the yield of peptide synthesis by the loading, swelling volume of the Rink Amide resin was studied. The factors, which affected the swelling volume of the resin, were also investigated. The results showed that the Rink Amide resin with lower loading, higher swelling volume benefited the yield of long peptide.

关 键 词：固相多肽合成 Rink Amide树脂 Fmoc-氨基酸 溶胀度 

分 类 号：O63[理学—高分子化学]