MMP-2和TIMP-2在小细胞肺癌患者血清中的表达及其临床意义  

Clinical Significance of Detection of Serum Expressions of MMP-2 and TIMP-2 in Patients with Small Cell Pulmonary Carcinoma

作　　者：彭亮[1] 

机构地区：[1]浙江省杭州市第一人民医院中心实验室,310006

出　　处：《放射免疫学杂志》2008年第6期523-524,共2页Journal of Radioimmanology

摘　　要：目的:探讨基质金属蛋白酶-2(MMP-2)和金属蛋白酶组织抑制因子-2(TIMP-2)在小细胞肺癌(SCLC)中的表达、两者相关性及临床病理意义。方法:采用放射免疫分析检测80例SCLC患者和35例正常人血清中的MMP-2、TIMP-2水平。结果:80例SCLC患者的MMP-2、TIMP-2血清水平明显高于正常对照组(P<0.01);广泛期SCLC患者的血清MMP-2和TIMP-2明显高于局限期患者(P<0.05)。结论:MMP-2和TIMP-2的高表达对SCLC的发生发展均起重要作用,两者表达水平与SCLC的浸润转移及恶性程度有关。Objective To investigate the clinical significance of changes of serum expressions of matrix metallo -proteinase 2 （MMP -2） and tissue inhibitors of metallo - proteinase 2 （TIMP -2） in patients with small ceU lung cancer （SCLC）. Methods Serum MMP -2 and TIMP -2 contents were measared with RIA in 80 patients with small cell lung cancer （SCLC） and 35 controls. Results The serum contents of MMP-2 and TIMP-2 in patients with SCLC were significantly higher than those in the controls （P 〈0.01 ）. Among the patients, the serum concentration of the two parameters in patients with wide- sprend disease were significantly higher than those in patients with localized disease （P 〈 0.05）. Conclusion Serum concentrations of MMP - 2 and TIMP - 2 were much increased in patients with SCLC, especially in patients with wide - spread disease.

关 键 词：小细胞肺癌 基质金属蛋白酶-2 金属蛋白酶组织抑制因子-2 

分 类 号：R734.2[医药卫生—肿瘤] R737.9[医药卫生—临床医学]