氨基糖苷类抗生素细菌内毒素的检测方法  

The Bacterial Endotoxin Test of Aminoglycoside Antibiotics

作　　者：程玉莲 李德贞[2] 赵凤琴[2] 吴迪 

机构地区：[1]齐齐哈尔市药品检验所,齐齐哈尔161006 [2]齐齐哈尔市第一医院,齐齐哈尔161005 [3]二道湾精神病疗养院

出　　处：《沈阳药科大学学报》1998年第1期71-72,共2页Journal of Shenyang Pharmaceutical University

摘　　要：参照ＵＳＰ（Ⅹ　Ⅻ）中鲎试法（ＬＴ法）最大有效稀释度（ＭＶＤＴ）公式，对６种氨基糖苷类抗生素进行ＬＴ法试验，以考察细菌内毒素检查法的可行性．实验结果表明，在ＭＶＤＴ公式给出的限度内合理稀释，ＬＴ法检查热原可行，与ＲＴ法相符率高．Referring to the formula of Maximum Valid Dilute Tolerance (MVDT) of Limulus TEST (LT) in USP(Ⅹ Ⅻ),we have tested six kinds of antibiotics by way of LT to check its feasibility. The result showed that the formula of MVDT is correct in the pyrogen examination by LT, as by RT.

关 键 词：氨基糖苷 抗生素 细菌内毒素 鲎试法 

分 类 号：R978.12[医药卫生—药品] R927.1[医药卫生—药学]