表皮生长因子及受体在甲状腺肿瘤中的表达  

The Expression of Epidermal Growth Factor and Epidermal Growth Factor Receptor in Thyroid Neoplasm

作　　者：王国瑞[1,2] 吴浩荣[1] 俞晓宇[3] 杨莉萍[2] 

机构地区：[1]苏州大学附属第二医院普外科,江苏苏州215004 [2]江苏省原子医学研究所附属江原医院外科,江苏无锡214002 [3]江苏省原子医学研究所附属江原医院病理科,江苏无锡214002

出　　处：《现代生物医学进展》2008年第12期2508-2510,共3页Progress in Modern Biomedicine

摘　　要：目的:研究表皮生长因子(Epidermal Growth Factor,EGF)及受体(Epidermal Growth Factor Receptor,EGFR)及在甲状腺肿瘤中的表达。方法:应用免疫组织化学法检测91例甲状腺病变组织中EGFR和EGF的表达情况。结果:结节性甲状腺肿、甲状腺腺瘤、分化型甲状腺癌标本中EGFR表达的阳性率分别为15%、25%、68.62%,EGF表达的阳性率分别为10%、15%、68.62%,其中EGFR、EGF在分化型甲状腺癌与其余两组间差异均有统计学意义(P<0.05)。EGFR和EGF在甲状腺乳头状癌中的表达与性别、年龄、肿瘤大小、淋巴结转移、临床分期等临床因素无明显相关。结论:EGF和EGFR的表达可作为鉴别甲状腺肿瘤良恶性的一个指标。Objective： To study the expression of epidermal growth factor （EGF）and epidermal growth factorreceptor （EGFR） in thyroid neoplasm. Methods： Immunohistochemical technique （SP method） was used to detect the expression of EGFR and EGF in 91 cases of thyroid neoplasm,and then the relationship between the expression and the major clinical pathological parameters was analyzed. Results： The positive rates of EGFR in nodular goiter, thyroid adenoma and differentiated thyroid cancer were 15 %,25 % and 68.62 %. The positive rates of EGF in nodular goiter, thyroid adenoma and differentiated thyroid cancer were 10 %, 15 % and 68.62 %. The results showed that the expression of EGFR, EGF in thyroid cancer was significantly higher than that in benign thyroid tumor （P〈0.05）. The expression of EGFR and EGF in papillary thyroid cancer was not correlated with the gender and the age of the patients,the diameter of the tumor,the presence of lymph nodes metastasis and the clinical stage. Conclusion： The expression of EGFR and EGF may be served as a marker in identifying thyroid cancer and thyroid innocuous node, but not so useful in assessing clinical characteristics of papillary thyroid cancer.

关 键 词：表皮生长因子 表皮生长因子受体 甲状腺肿瘤 

分 类 号：R736.1[医药卫生—肿瘤]