非酒精性脂肪性肝病患者的血浆Ghrelin水平与颈动脉粥样硬化的相关性  

Correlation analysis of ghrelin level and carotid atherosclerosis in non-alcoholic fatty liver disease

作　　者：陈宁[1] 杨明[2] 黄锦平[3] 

机构地区：[1]江苏淮安市第三人民医院老年内科,江苏省淮安市223001 [2]海军总医院检验科,北京市100037 [3]江苏省淮安市第三人民医院功能科,江苏省淮安市223001

出　　处：《世界华人消化杂志》2008年第34期3890-3893,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨非酒精性脂肪性肝病(NAFLD)患者血浆Ghrelin水平与颈动脉粥样硬化是否有关.方法:NAFLD患者(101例),按是否有颈动脉粥样硬化分为2组,对患者年龄、病程、体质量指数(BMI)、体脂肪含量(Fat%)、血压(SBP、DBP)、空腹血糖(FBG)、血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、瘦素(LEP),Ghrelin水平等动脉粥样硬化危险因素进行多变量分析.结果:两组在年龄(60.1±10.7vs41.9±11.6,t=8.13,P<0.01)、DBP(11.5±2.4vs10.1±3.5,t=2.39,P<0.05)、Fat%(30.8±8.4vs26.7±7.1,t=2.58,P<0.05)、病程(96.2±61.3vs69.4±58.9,t=2.20,P<0.05)方面经统计学处理有显著性差异.血清生化指标两组在TC(7.4±0.8vs5.1±0.7,t=2.61,P<0.05)、LDL-C(3.3±0.6vs2.8±0.5,t=4.41,P<0.001)、LEP(7.1±2.2vs5.8±2.5,t=2.76,P<0.01)、Ghrelin水平(5.97±1.26vs6.59±1.16,t=2.54,P<0.05)方面比较有显著性差异.NAFLD患者发生颈动脉粥样硬化危险因素多变量分析:与Ghrelin水平下降(r=-0.565,P<0.05)、舒张压(r=-0.615,P<0.01)和LDL-C(r=-0.571,P<0.05)独立相关.结论:血浆Ghrelin水平下降可能是NAFLD患者颈动脉粥样硬化发生的重要因素.AIM： To determine whether serum ghrelin level is an independent factor associated with carotid atherosclerosis in non-alcoholic fatty liver disease. METHODS： One hundred and one patients with non-alcoholic fatty liver disease were divided into 2 groups based on presence of carotid atherosclerosis. Ghrelin level and other non-alcoholic fatty liver disease risk factors including age, course of disease, percentage of fat （Fat%）, body-mass index （BMI）, free blood glucose （FBG）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, serum cholesterol （TC）, triglyceride （TG）, and liver function, high density lipoprotein （HDL-C）, low-density lipoprotein （LDL-C）, leptin and ghrelin level after multivariate analysis. RESULTS： Significant differences in age （60.1 ± 10.7 vs 41.9 ± 11.6, t = 8.13, P 〈 0.01）, DBP （11.5 ± 2.4 vs 10.1 ± 3.5, t = 2.39, P 〈 0.05）, percentage of fat （30.8 ± 8.4 vs 26.7 ± 7.1, t = 2.58, P 〈 0.05） and course of disease（96.2 ± 61.3 vs 69.4 ± 58.9, t = 2.20, P 〈 0.05） were observed between the two groups. Remarkable differences between two groups were also observed in TC （7.4 ± 0.8 vs 5.1 ± 0.7, t = 2.61, P 〈 0.05）, LDL-C （3.3 ± 0.6 vs 2.8 ± 0.5, t = 4.41, P 〈 0.001）, LEP （7.1 ± 2.2 vs 5.8 ± 2.5, t = 2.76, P 〈 0.01） and ghrelin level （5.97 ± 1.26 vs 6.59 ± 1.16, t = 2.54, P 〈 0.05）. Multivariate analysis showed that carotid atherosclerosis was associated with decreased ghrelin level （r = -0.565; P 〈 0.05）, DBP （r = -0.615; P 〈 0.01） and LDL-C （r = -0.571, P 〈 0.05）. CONCLUSION： Decreased ghrelin level may be an important risk factor in pathogenesis of carotid atherosclerosis in patients with non-alcoholic fatty liver disease.

关 键 词：GHRELIN 非酒精性脂肪性肝病 颈动脉 粥样硬化 

分 类 号：R575[医药卫生—消化系统] R543[医药卫生—内科学]