儿童急性白血病免疫表型及临床研究  

Immune Phenotype and Clinical Study of Childhood Acute Leukemia

作　　者：黄婕[1] 何璐璐[1] 方拥军[1] 芮耀耀[1] 周莉[1] 陆勤[1] 杨引[1] 

机构地区：[1]南京医科大学附属南京儿童医院,江苏南京210008

出　　处：《医学临床研究》2008年第12期2159-2161,共3页Journal of Clinical Research

摘　　要：【目的】探讨儿童急性白血病(AL)免疫表型抗原分布情况及其与临床表现及疗效的关系。【方法】用流式细胞术对78例初诊AL患儿进行免疫分型。【结果】64例急性淋巴细胞白血病(ALL)患儿中45.3%表达髓系抗原,14例急性髓系白血病(AML)患儿43.8%伴有淋系相关抗原的表达。CD34+ALL及CD34-ALL在性别、年龄、初诊时白细胞计数上差异无统计学意义,但在肝脾淋巴结肿大等髓外浸润表现上差异有统计学意义(χ2=5.24,P=0.025),在诱导治疗4周的缓解率上差异无统计学意义。伴有髓系抗原表达的ALL(My+ALL)与My-ALL在强的松试验反应及4周缓解率上差异无统计学意义(P>0.05)。B-ALL与T-ALL在诱导治疗四周缓解率并无差异,但T-ALL较B-ALL更易复发,预后更差。【结论】儿童AL的免疫分型有助于指导临床治疗及判断预后。[Objective] To investigate the immune phenotype distribution of childhood acute leukemia （AL） and its relationship with clinical characteristics and therapy effectiveness. [Methudsl Immune phenotype of 78 children with newly diagnosed acute leukemia was determined with flow cytometry. [Results] Of the 64 acute lymphoblastic leukemia （ALl.） children, 45.3% expressed myeloid antigens, while of the 14 acute myeloid leukemia （AML） patients, 43.8% had lymphoid associated antigens. There were no differences between CD34＋ and CD34 ALL with regard to sex, age, white blood count at diagnosis. But differences existed in ex- tramedullary manifestations such as enlargement of liver, spleen and lymphnodes （χ^2 =5.24, P =0. 025）, although there was no difference in 4-week remission rate of induction therapy between the two groups. Between ALL with myeloid antigen （My＋ ALL） group and My ALL group, there was no difference in 4-week remission rate of prednisone trial （ P 〉0. 05）. Although there was no difference in 4-week remission rate of induction therapy between B-ALL and T ALL, T-ALl. tended to have more relapse than B-ALL, and with a worse prognosis. [Conclusion] Immune phenotype classification is helpful in guiding clinical therapy and predicting prognosis.

关 键 词：白血病/免疫学 急性病 

分 类 号：R733.7[医药卫生—肿瘤]