芬太尼透皮贴剂与口服吗啡控释片治疗老年中重度癌痛疗效比较  

A comparison between transdermal fentanyl and oral controlled-release morphine in the treatment of moderate and severe cancer pain in elderly patients

作　　者：赵月霞[1] 黄丽娟[1] 

机构地区：[1]宁夏医学院附属医院老年科,宁夏银川750001

出　　处：《临床和实验医学杂志》2008年第12期31-32,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的比较芬太尼透皮贴剂与口服吗啡用于老年癌痛患者的疗效和不良反应。方法86例老年癌痛患者,随机分为两组。A组使用芬太尼透皮贴剂,B组口服吗啡控释片,比较两组的疗效和不良反应情况。结果两组用药后止痛效果明显,A组总缓解率90.70,B组总缓解率93.02,差异无显著性(P>0.05);A组不良反应明显低于B组,差异有显著性(P<0.05),尤其死两组便秘发生率有极显著差异(P<0.01)。结论芬太尼透皮贴剂镇痛安全方便,疗效确切,是治疗老年中重度癌痛的理想药物。Objective To study the effect and safety of transdermal fentanyl and oral controlled - release morphine in the treatment of moderate and severe cancer pain in elderly patients. Methods Eighty - six elderly patients （ age ≥ 60） with moderate and severe cancer pain were randomly divided into two groups. Group A was treated with transdermal fentanyl, and group B with oral controlled - release morphine. The therapeutic efficacy and adverse reaction of the drugs were observed. Results The overall analgesic response rates in group A and group B were 90.70% and 93. 02% respectively （ P 〉 0.05 ）. The incidence of adverse reaction was lower in group A than that in group B （ P 〈 0.05 ）. The incidence of constipation was significantly different between the two groups （ P 〈 0.01 ）. Conclusion Transdermal fentanyl is safe, convenient and effective. It is recommended as a first - line drug for the treatment of elderly patients with moderate to severe cancer pain.

关 键 词：芬太尼透皮贴剂 吗啡控释片 老年患者 癌痛 疗效 不良反应 

分 类 号：R730.5[医药卫生—肿瘤]