骨桥蛋白在乳腺癌组织中的表达及意义  

Expression of Osteopontin in Breast Carcinoma

作　　者：高亚丽[1] 邢鲁奇[1] 

机构地区：[1]河南科技大学第一附属医院,河南洛阳471003

出　　处：《河南科技大学学报（医学版）》2008年第4期251-253,共3页Journal of Henan University of Science & Technology:Medical Science

基　　金：洛阳市应用技术研究与开发资金项目(0802021A)

摘　　要：目的探讨骨桥蛋白(OPN)在乳腺癌组织中的表达及意义。方法采用免疫组化SP法检测86例乳腺浸润性导管癌组织OPN的表达情况,分析其表达与病理特征和预后的关系。结果在86例浸润性导管癌中,OPN阳性表达率为53.5%,在Ⅰ、Ⅱ、Ⅲ级癌组织中的阳性率分别是38.1%、47.3%、74.7%,有、无淋巴结转移组阳性率分别是72.2%和40.0%,生存期≥5年和<5年的表达率分别是38.9%和78.1%;OPN的表达与5年生存率呈明显负相关(P<0.05)。COX比例风险模型多因素的预后分析显示淋巴结转移和组织学分级是预测乳腺癌预后的独立指标。结论乳腺癌组织中OPN的表达明显升高,OPN的表达与乳腺癌患者的组织学分级,淋巴结转移呈正相关,与5年生存率呈负相关,但OPN不能作为预测乳腺癌预后的独立指标。Objective To explore the expression of OPN and its significance in breast carcinoma. Methods SP immunohistochemical method was used to examine the expression of OPN in 86 cases of breast carcinoma and analyze its relationship with clinical pathological characteristics and survival rate of 5 years. Results The positive rates of OPN was 53.5% （46/86）. It was 38. 1% ,47.3% ,74.7% in carcinomas with grade Ⅰ , Ⅱ and Ⅲ respectively, 72.2% and 40.0% in lymph nodes metastases positive group and negative group ,38.9% and 78.1% among patients who survived more than 5 years and less than 5 years respectively; The expression of OPN had negative relationship with survival of rate 5 years （ P 〈 0. 05 ）. Cox model revealed that lymph nodes metastases and grade of histology were independent prognostic factors in breast carcinoma. Conclusion OPN is highly expressed in breast carcinoma, and positively correlated to grade of histology and lymph nodes metastases, and negatively correlated to survival rate of 5 years. OPN is not an independent prognostic factor in breast carcinoma.

关 键 词：骨桥蛋白 乳腺癌 预后 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]