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作 者:李永芳[1] 寇毅英[1] 杨梅[1] 冯伟力[1] 格日力[1]
机构地区:[1]青海大学医学院,西宁810001
出 处:《中国现代应用药学》2008年第6期487-490,共4页Chinese Journal of Modern Applied Pharmacy
基 金:青海大学医学院资助项目(青医科技-2004-003)
摘 要:目的研究八味沉香散对异丙肾上腺素(ISO)诱导大鼠心肌缺血损伤组织病理学、氧化-抗氧化系统的影响。方法大鼠50只,随机分为正常对照组,模型对照组,阳性对照组(心得安0.02 g.kg-1),八味沉香散1.0 g.kg-1和0.5 g.kg-1组。均灌胃给药,每天1次,连续10 d。除正常对照组外,其余各组均于第8,9,10 d灌胃给药30 m in后腹腔注射ISO 5 mg.kg-1,每天1次,连续3 d。末次给ISO后24 h,取心观察组织形态学改变,同时测定心肌组织大鼠SOD、GSH-Px、NOS活性以及NO和MDA含量。结果与正常对照组比,模型对照组心肌SOD和GSH-Px活性明显降低,iNOS活性、MDA和NO含量明显升高,心肌组织严重受损;预先给予八味沉香散可明显升高心肌SOD和GSH-Px活性,降低MDA、NO含量和iNOS活性,并减轻心肌组织损伤。结论八味沉香散对ISO致大鼠心肌缺血损伤具有保护作用,其作用机制与减少活性氧产生,增强抗氧化剂活性,阻断脂质过氧化有关。OBJECTIVE To study the effect of Baweichenxiang powder on myocardial pathologic change, myocardium lipid peroxidation and antioxidation in rats with isoproterenol(ISO)-induced myocardial injury. METHODS Fifty rats were random divided into nomal control group, model control group, propranolol group, Baweichenxiang powder 1.0 g · kg^-1 group and 0.5 g· kg^-1 group. All rats were administered orally daily for a period of 10 days. A myocardial ischemia model on rats was established by intraperitoneal injection of isoproterenol 5 mg· kg^-1 once a day for consecutive 3 days. After ip ISO 24 h, the hearts were dissected and examined with microscope,the activities of SOD, GSH-Px and NOS and the contents of MDA and NO were measured. RESULTS In the ISO group, the myocardium activities of SOD,GSH-Px were significantly decreased (P 〈0.01 ), the contents of NO and MDA and the activity of iNOS were higher than those in the normal control group. Compared with the ISO group, Baweichenxiang powder 1.0 g · kg^-1 group and 0.5 · kg^-1 group significantly increased the activities of SOD and GSH-Px and reduced the contents of NO and MDA and the activity of iNOS. The rats in both Baweichenxiang powder 1.0 g · kg^-1 group and 0.5 g · kg^-1 group showed less histological changes than that in the ISO group. CONCLUSION The protective effects of Baweichenxiang powder on the myocardial injury induced by isoproterenol may be related to reducing the oxygen free radicals, protecting the antioxidants and inhibiting the lipid peroxidation in the myocaydium.
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