兰索拉唑与奥美拉唑治疗消化性溃疡的比较  

Lansoprazole vs omeprazole in treating peptic ulcer

作　　者：王平[1] 杨见权[1] 刘振坚[1] 刘源强 高嘉慧 柳永刚[1] 

机构地区：[1]暨南大学医学院附属医院消化科,广东广州510630

出　　处：《中国新药与临床杂志》1998年第1期35-36,共2页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察兰索拉唑对消化性溃疡的疗效并与奥美拉唑进行比较。方法 :64例经内镜确诊的消化性溃疡病人分为 2组。兰索拉唑组 36例 (男性2 8例 ,女性 8例 ,年龄 4 1±s 8a)用兰索拉唑 30mg ,po ,qm× 4wk ;奥美拉唑组 2 8例 (男性 2 2例 ,女性 6例 ,年龄 4 2± 10a)以奥美拉唑 2 0mg ,po ,qm× 4wk。结果 :2组在溃疡愈合率 ( 89%vs90 % )、总有效率 ( 94 %vs 93% )和d 7腹痛缓解率( 97%vs 96% )均无显著差异 (P均 >0 .0 5)。但d 3腹痛缓解率兰索拉唑组显著高于奥美拉唑组 ( 83%vs 71% ,P <0 .0 5)。 2组不良反应均轻微。结论AIM: To observe the efficacy of lansoprazole in treating peptic ulcer in comparison with omeprazole. METHODS: Patients (n=64) with peptic ulcer were divided randomly into 2 groups: 36 patients (M 28, F 8, age 41±s 8 a) in treatment group received lansoprazole 30 mg, po, qm for 4 wk; 28 patients (M 22, F 6, age 42±10 a) as control received omeprazole 20 mg, po, qm for 4 wk. RESULTS: No significant differences in the total response rates(94%vs 93%), ulcer healing rate (89%vs 90%) and the pain relief on d 7 (97%vs96%) were found between in the treatment and control groups (P>0.05, respectively). The pain relief rates on d 3 in the treatment group showed better ef_ fect than those in the control(83% vs 71%, P< 0.05). The adverse reactions in 2 groups were mild. CONCLUSION: Lansoprazole has a excellent therapeutic effect on peptic ulcer.

关 键 词：消化性溃疡 兰索拉唑 奥美拉唑 药物疗法 

分 类 号：R573.105[医药卫生—消化系统] R975.6[医药卫生—内科学]