帕罗西汀麦普替林治疗脑卒中后抑郁的对照观察  

Control Study of Paroxetine and Maprotiline in Treatment of Post-stroke Depression

作　　者：马闯胜 张淑芳 杨靖 

机构地区：[1]郑州市第八人民医院,郑州市450006

出　　处：《医药论坛杂志》2008年第23期17-19,共3页Journal of Medical Forum

摘　　要：目的比较帕罗西汀和麦普替林治疗脑卒中后抑郁的疗效和不良反应。方法把符合入组条件的68例患者随机分成帕罗西汀组和麦普替林组,分别给予相应药物治疗。研究共观察8周,在治疗前和治疗的第2、4、6、8周末应用汉密尓顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效,记录治疗过程中的不良反应。结果治疗过程中脱落5例。治疗后两组患者HAMD、HAMA评分均较治疗前明显下降(P<0.01),两组间同期比较差异无统计学意义(P>0.05);帕罗西汀组有效率84.38%,麦普替林组有效率87.10%,二者差别无统计学意义(P>0.05);帕罗西汀组不良反应少于麦普替林组,在口干便秘、排难困难、嗜睡等方面两组间差别有统计学意义(P<0.05)。结论帕罗西汀治疗脑卒中后抑郁疗效与麦普替林相当,不良反应少。Objective To compare the efficacy and side effects of aroxetine and maprotiline in the treatment of post - stroke depression. Methods Total 68patients with post - stroke depression were randomly divided into paroxetine group and maprotiline group for 8 weeks, clinical efficacies were assessed with Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale （HAMA） before treatment and the ends of 2,4,6,8 week treatment, noted the side effect at the same time. Results Total 5patients were missing. The scores of HAMD, HAMA reduced significantly after treatment in both groups （P 〈 0. 05 ） , No significant difference was found between paroxetine group and maprotiline group （P 〉 0. 05 ）. The effective rate of paroxetine group and maprotiline group were 84.38% and 87. 10% ,there were no significant difference （P 〉 0. 05）. The side effects of paroxetine group was less significantly than that in maprotiline group in dysuria, somnolence, thirst and constipation （P 〈 0.05 ） . Conclusion Paroxetine was an effective drug in the treatment of post - stroke depression like maprotiline, and the side effect was less than maprotiline.

关 键 词：帕罗西汀 麦普替林 脑卒中后抑郁 

分 类 号：R749.13[医药卫生—神经病学与精神病学]