耐力训练对饮食性肥胖大鼠胰岛素作用的影响  

TX Effects of Endurance Training on Insulin Action in Dietary Obese Rats

作　　者：王从容[1] 杨锡让 刘亚兵[1] 姚文贞[1] 王敬泽[1] 

机构地区：[1]北京体育大学,中国科学院动物研究所

出　　处：《中国运动医学杂志》1998年第1期16-19,共4页Chinese Journal of Sports Medicine

摘　　要：为观察耐力训练对饮食性肥胖鼠胰岛素作用的影响，选用４４只雄性离乳ＳＤ大鼠，３６只饲以高脂饲料。饲养１０周后，１８只确定为饮食诱发肥胖鼠（ＤＩＯ），其中８只进行耐力训练（跑台６５－７５％Ｖｏ２ｍａｘ），所有大鼠继续饲养８周后处死。测定各组大鼠的血中胰岛素，细胞膜胰岛素受体。处死前进行葡萄糖负荷实验。实验结果如下：肥胖鼠存在高胰岛素血症，胰岛素敏感性下降及胰岛素抵抗，葡萄糖负荷实验，血胰岛素分泌峰值和分泌曲线下面积均增加，细胞膜胰岛素受体结合下降。耐力训练可通过增加肝细胞、脂肪细胞和白肌细胞膜胰岛素受体结合力，减轻胰岛素抵抗，提高胰岛素敏感性，改善高胰岛素血症。提示，高胰岛素血症，胰岛素敏感性下降及胰岛素抵抗是高脂饲料诱发肥胖大鼠的特征之一，耐力训练是通过改善肥胖鼠的代谢失常而降低其体脂的有效方法。This study was to clarify the effects of the effects of endurance training on insulin action in dietary obese rats.36 of 44 male weaning SD rats were fed with high fat diet for 10 weeks,of which 18 rats became dietary obese(DIO). 8 DIO rats underwent endurance training with treadmill (65 - 75% V02 max). All rats continued feeding foranofher 8 weeks.Plasma insulin,glucose load,and plasma membrane insulin.receptor bindingradioimmunoassay and radioligand receptor assay in the rats were determined.Results showed that hyperinsulinemia, low insulin sensitivity and insulin resistance appeared, the area below plasma insulin secretary curve and insulin peak value of glucose load were increased,and the insulin receptor binding decreased in DIO rats. Endurance training could abate insulin resistance, enhance insulin sensitivity and lower the level of hyperinsulinemia through increasing insulin receptor binding in hepatocytes, adipocytes and white myocytes membranes. lt was demonstrated that hyperinsulinemia, low insulin sensitivity and insulin resistance were the characteristics of DIO rats, and endurance training was the effective measure for reducing body fat by modifying metabolic disorder in DIO rats.

关 键 词：肥胖 胰岛素 受体 耐力训练 

分 类 号：R151.1[医药卫生—营养与食品卫生学]