肝硬化、门静脉狭窄大鼠胃粘膜屏障功能异常的研究  

A Study on the Abnormal Barrier Capability of Gastric Mucosa in Cirrhosis and Portal Vein Stenosis in Rats

作　　者：周东风[1,2] 刘鹏飞[1,2] 梁桂华[1,2] 孙作祥 王占民[1,2] 寿楠海 

机构地区：[1]济宁医学院附属医院肝胆外科 [2]山东医科大学附属医院普外科

出　　处：《中国普通外科杂志》1998年第1期17-20,共4页China Journal of General Surgery

摘　　要：为观察门静脉高压时胃粘膜的屏障功能，研究设计肝硬化和肝外门静脉狭窄两组门静脉高压动物模型，观察其胃粘膜屏障功能的变化并与正常对照组对比研究。结果显示：门静脉高压大鼠内脏血流量明显增加，而胃粘膜实际处于局部缺血状态；胃壁结合粘液量（ＧＰ）和胃粘膜ＰＧＥ２含量较对照组显著降低，尤以肝硬化门静脉高压大鼠为甚；胃基础泌酸量（ＢＡＳ）三组间无差异，而门静脉高压大鼠Ｈ＋返流量（Ｈ＋ＢＤ）明显高于对照组，以肝硬化大鼠最为显著。结果表明：门静脉高压性胃病（ＰＨＧ）的发生与胃粘膜屏障功能严重削弱有关；而非“高酸”所致；肝功能受损参与胃粘膜病变的发生。In order to observe the barrier capability of gastric mucosa in portal hypertension (PHT), we designed a cirrhosis and an extrahepatic portal vein stenosis models of portal hypertension in rats respectively. The results demonstrated that the splanchnic blood flow of the portal hypertensive rats increased significantly, but the gastric mucosa was actually ischemic, the content of mucus (glycoprotein GP) in the gastric wall and that of PGE2 in the gastric mucosa decreased specially in cirrhotic portal hypertensive rats; There is no significant difference in the amount of the basal acid secretion (BAS) in the three groups, but the amount of H+ backdiffusion (H+BD) obviously increased in PHT groups compared with the control group, and the highest one was the cirrhotic PHT rats. The experimental results suggest that the barrier capability of gastric mucosa in portal hypertension groups was lower than that in the control group and the lowest one was the cirrhotic portal hypertensive rats. The portal hypertensive gastropathy (PHG) is associated with the lower capability of defense of gastric mucosa and is not caused by “hyperacid”. The condition of liver function also influences the barrier capability of gastric mucosa.

关 键 词：肝硬变 门静脉高压症 胃粘膜 屏障功能 

分 类 号：R575.2[医药卫生—消化系统]