自制自膨式金属内支架的动物实验研究  

Experimental study in rabits using the home-made stent shape memory alloy

作　　者：郭建魁[1] 张仲慧[1] 李冬青[1] 乔建民[1] 陈玉利[1] 秦玉霞[1] 

机构地区：[1]开滦(集团)有限责任公司医院,河北省唐山市063000

出　　处：《河北医药》2008年第12期1873-1874,共2页Hebei Medical Journal

摘　　要：目的研究自制自膨式金属内支架的生物相容性及通畅情况。方法通过介入手术方式将自制自膨式镍钛合金金属内支架放置于近交系大白兔的食管中,术后一段时间内,处死实验动物,观察植入自膨式支架后食管通畅情况及内膜增生机制。结果30只实验动物中,2只通畅良好,28只存在不同程度增生致部分狭窄,其中3只完全阻塞。支架周边组织光镜检查,发现支架表面部分有上皮细胞覆盖,但主要为纤维结缔组织增生和支架所在组织的细胞增生。增生的组织细胞成分与支架植入后的时间长短有关,随支架留置时间的延长,支架周围的结缔组织增生明显加重,且支架周围有淋巴组织增生。结论选择好合适的内支架和植放部位,可使内支架狭窄产生的时间延长。Objectve To observe the biological compatibility of home-made NiTi-stent. Methods Stents were implanted within the esophageal of rabbits. Experimental animal was killed according to the schedule to observe the patency of stents and mechanism of intima hyperplasia. Rusults In the thirty of rabbits, two rabbits were patent, twenty-eight rabbits were partially patent. Among of the twenty-eight, three rabits were occluded completedly. Epithelium tissues were found along the surface of stents. Both sides of the stents were coverd by the epithelium cells partially and dominatd by the proliferation of fibrous connective tissus and parenchymal cells of the organs. The constitution of proliferated tissues was related to the implanted time period of the stentts. No fibrous connective tissues were found within two weeks, but obvious proliferation of fibrous connective tissues were found associated with lymphadenia. Conclusion Good results can be yielded by selecting the suitable stent and the implanting site.

关 键 词：记忆合金 内支架 动物 实验 

分 类 号：R735.1[医药卫生—肿瘤] R-332[医药卫生—临床医学]