人原发性肝癌及癌周肝组织中C-myc基因的表达  

THE EXPRESSION OF C MYC GENE IN PRIMARY HEPATOCELLULAR CARCINOMA AND ITS PERICARCINOMATOUS TISSUE

作　　者：牛兆山[1] 张昭成[1] 李慎谦[1] 邹伟[1] 

机构地区：[1]青岛医学院

出　　处：《青岛医学院学报》1998年第1期16-17,共2页Acta Academiae Medicinae Qingdao Universitatis

基　　金：山东省教委科研基金

摘　　要：①目的探讨癌周肝组织与肝癌组织发生之间的关系。②方法应用免疫组织化学方法对６０例原发性肝癌及其癌周组织中Ｃ－ｍｙｃ基因进行检测。③结果Ｃ－ｍｙｃ基因在肝癌和癌周增生结节及癌周肝硬变组织中的阳性率分别为３８．３％（２３／６０），４０．５％（１５／３７）和２６．７％（８／３０）。经统计学处理，肝癌与增生结节、肝硬变组织间差异均无显著性（χ２＝０．０５，１．２１，Ｐ均＞０．０５），增生结节与肝硬变组织间差异亦无显著性（χ２＝１．４１，Ｐ＞０．０５）。④结论Ｃ－ｍｙｃ癌基因过度表达是肝癌癌变过程中的重要因素；Ｃ－ｍｙｃ癌基因的过度表达可能与癌周增生结节的恶性转化有较密切的关系。癌周增生结节属癌前期病变。Objective To study the relationship between the pericarcinomatous tissues and hepatocarcinogenesis. Methods C myc gene expression was detected immunohistochemically in 60 cases of hepatocellular carcinoma(HCC) and their pericarcinomatous tissues. Results The positive rates of C myc gene expression in HCC, hyperplastic nodules and liver cirrhosis in the pericarcinomatous tissues were 38.3%(23/60),40.5%(15/37) and 26.7%(8/30) respectively. The differences between HCC and hyperplastic nodules, liver cirrhosis in pericarcinomatous tissue were not significant( χ 2=0.05,1.21,P>0 05) . Conclusion Overexpression of C myc gene is an important factor in the development of HCC; C myc overexpression may be closely related to the malignant transformation of hyperplastic nodules in the pericarcinomatous tissues. Hyperplastic nodules in the pericarcinomatous tissues were preneoplastic lesions, and were related to hepatocarcinogenesis.

关 键 词：肝肿瘤 癌基因 免疫组织化学 C-MYC基因 

分 类 号：R735.702[医药卫生—肿瘤]