结直肠肿瘤患者血清CEA和CA19-9检测的价值  

Clinical significance of serum CEA and CA19-9 in patients with colorectal cancer

作　　者：赵建香[1] 孟令国[1] 许栋[1] 

机构地区：[1]泰山医学院附属医院检验科,山东泰安271000

出　　处：《泰山医学院学报》2008年第10期785-786,共2页Journal of Taishan Medical College

摘　　要：目的探讨结直肠肿瘤患者化疗前后血清CEA和CA19-9水平的变化及有无腹水患者的这两种标志物的差异与血清和腹水联合检测CEA与CA19-9水平对提高临床诊断水平及疗效的观察意义。方法采用化学发光法和放射免疫分析法两种方法共检测了36例结直肠肿瘤患者化疗前后及有无腹水时血清中CEA和CA19-9两种标志物的水平和腹水中两种标志物的含量,并与36例健康人进行了比较。结果结直肠肿瘤患者化疗前两种标志物的水平显著高于正常人(P<0.01),化疗后水平下降明显(P<0.01),还发现腹水中的水平明显高于血清中(P<0.01),且血清与腹水同时检测阳性率明显高于单项检测。结论结直肠肿瘤患者血清及腹水中CEA及CA19-9的检测是诊断及判断疗效的重要指标。Objective： To investigate serum CEA and CA19 -9 level changes before and after chemotherapy in patients with colorectal cancer, and difference between these two markers in patients both with and without ascites. Methods： Using chemiluminescence and RIA two methods, the contents of the two markers were detected before and after chemotherapy in 36 cases of colorectal cancer in the cases of no t having ascites and having ascites. The results were compared with those of 36 cases of healthy people. Results ： The two markers of the level were significantly higher than those in normal subjects in colorectal cancer patients before chemotherapy （P 〈 0.01 ） But the levels decreased significantly after chemotherapy （P 〈 0. 01 ）, It was also found the level in ascites was significantly higher than that （ P 〈 0.01） in serum. And the positive rate of the level in ascites and the serum at the same time was significantly higher than that of single detection. Conclusion ： The CEA and CA19 -9 detection in the serum and ascites are the important indicators in the diagnosis and judgment of colorectal cancer patients.

关 键 词：CEA CA19—9 结直肠肿瘤 腹水 

分 类 号：R735.3[医药卫生—肿瘤]