恶性肿瘤患者促红细胞生成素浓度检测和相关性分析  

Study on the level of serum erythropoietin in cacer patient.

作　　者：冯岗[1] 邓文斌[1] 唐桦[1] 王晋[1] 张羽[1] 杜小皮[1] 姚兵[1] 李慧[1] 唐诗添[1] 

机构地区：[1]绵阳市中心医院肿瘤科检验科,四川绵阳621000

出　　处：《四川医学》2008年第12期1604-1605,共2页Sichuan Medical Journal

基　　金：四川省卫生厅科研基金(编号:050273)

摘　　要：目的了解恶性肿瘤患者体内促红细胞生成素的水平,为临床治疗提供参考。方法采用酶联免疫法测定77例肿瘤患者的促红细胞生成素(erythropoietin,EPO)含量和血常规,同时以20例健康查体的正常人为对照,分析EPO含量同血常规的关系。结果健康人群的EPO含量为(17.32±10.20)mIU/ml,恶性肿瘤患者为(44.34±35.26)mIU/ml(P<0.01)。其中不贫血的肿瘤患者EPO含量为(21.92±14.35)mIU/ml,贫血的肿瘤患者EPO含量为(51.18±36.95)mIU/ml,(P<0.01)。曾经做过化疗的肿瘤患者EPO含量为(28.08±18.23)mIU/ml,没有化疗的患者为(59.39±40.41)mIU/ml(P<0.01)。行含铂方案化疗患者的EPO含量为(22.26±14.26)mIU/ml,不含铂方案化疗的患者为(37.64±20.44)mIU/ml(P=0.011)。恶性肿瘤EPO含量同HGB和HCT的相关系数分别为-0.581和-0.548(P=0.01)。结论恶性肿瘤患者EPO水平比正常人显著升高,化疗特别是含铂方案化疗会导致EPO明显降低。恶性肿瘤患者EPO含量同HGB和HCT线性负相关而且可能同患者的预后有关。Objective To study on the level of serum erythropoietin in cancer patient. Methods We check the erythropoietin and the hemogram in 77 cancer patients and 20 cases of healthy volunteers by ELISA. The relationship between EPO and hemo ,gram was analyzed. Results The serum Epo level in healthy volunteers and cancer patients was 117.32 ± 10.20） mIU/ml and 144.34 ± 35.26） mIU/ml（ P 〈 0.01）. The EPO level in cancer patients with anemia and the others is （51.18 ± 36.95 ） mIU/ml and （21.92 ± 14.35） mIU/ml（P 〈 0.01 ）. The serum EPO in cancer patients with or w-ithout chemotherapy is （ 28.08 ± 18.23 ） mlU/ml and （59.39 ± 40.41 ） mIU/ml（ P 〈 0.01） .The coefficient correlation between the EPO and HGB and HCT is -0.518 and -0.548. Conclusion The serum EPO in cancer patient was much higher than that in healthy volunteers. Chemotherapy would reduce The EPO level .The serum EPO had coefficient correlation with HGB and HCT,and might be used as prognosis.

关 键 词：促红细胞生成素 肿瘤性贫血 

分 类 号：R730.4[医药卫生—肿瘤]