影响食管癌FDG摄取的临床因素探讨  

Analysis of Clinical Factors Impacting FDG Uptake in Primary Esophageal Carcinoma

作　　者：冯瑞[1] 李明焕[2] 孔莉[1] 周伟[1] 杨国仁[1] 于金明[1] 

机构地区：[1]山东省肿瘤医院放疗科,济南市250117 [2]山东省肿瘤医院核医学科,济南市250117

出　　处：《中国肿瘤临床》2008年第24期1381-1384,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助(编号:30700196)~~

摘　　要：目的:研究性别、年龄、病变长度、肿瘤浸润深度、以及淋巴结状况等因素对食管癌原发灶FDG摄取的影响。方法:收集2004年6月至2006年11月治疗前行FDG-PET/CT检查的食管鳞癌患者68例,根据术后病理确定其病变长度、浸润深度、以及淋巴结转移情况。分析性别、年龄、病变长度等因素对食管癌原发灶FDG摄取(SUVmax)的影响,并分析转移状态(无转移、局部淋巴结转移)、TNM分期与FDG摄取的相关性。结果:不同性别、不同年龄段食管癌患者的原发灶FDG摄取无明显差异。而病变长度影响FDG摄取:病变长度与其FDG摄取呈正相关(P=0.01)。不同TNM分期、不同转移状态间原发灶的FDG摄取也有显著性差异,浸润深度,淋巴结转移状态均与SUVmax呈正相关(P=0.000)。结论:食管癌原发灶FDG摄取与病变长度、TNM分期等因素有关,而不受性别和年龄影响关,键而词且FD食G管摄肿取瘤值较原高发还灶提示发已射经型有计淋算巴机结转脱移氧或葡分萄期糖较晚。Objective： To investigate the influences of gender, age, tumor length, depth of infiltration, and lymph node status on the fluorodeoxyglucose （FDG） uptake of esophageal carcinoma. Methods： From June 2004 to November 2006, 68 patients with pre-surgical esophageal carcinoma who were newly diagnosed by whole body 18F-fluorodeoxyglucose PET/CT imaging were enrolled. Tumor length, invasive depth, and lymph node status were determined using postoperative pathology. We analyzed the effect of gender, age, tumor length, metastasis, and TNM staging on FDG uptake. Results： A significant difference was found in FDG uptake values of primary lesions among groups with lesions of different length. There was no statistical significance in FDG uptake values among groups of different ages or genders. There was a positive correlation between the SUVmax and the invasive depth （P=0.000）. A significant difference was also found in FDG uptake between the group with lymph node metastasis and the group without lymph node metastasis （P=0.000）. SUVmax was positively correlated with lymph node metastasis and invasive depth （r=0.852, P=0.000）. Conclusion： The length and depth of primary lesions are correlated to FDG uptake in esophageal carcinoma patients. Increased maximum standardized uptake value of the primary lesion may indicate lymph node metastasis and late stage esophageal carcinoma.

关 键 词：食管肿瘤 原发灶 发射型计算机 脱氧葡萄糖 

分 类 号：R735.1[医药卫生—肿瘤]