神经生长因子与肝纤维化的研究进展  

Progress in nerve growth factor and hepatic fibrosis

作　　者：李方春[1] 

机构地区：[1]江西省丰城市人民医院传染科,331100

出　　处：《国际流行病学传染病学杂志》2008年第6期426-427,共2页International Journal of Epidemiology and Infectious Disease

摘　　要：肝星形细胞（HSC）活化是肝纤维化形成的关键因素。目前研究显示，神经生长因子（NGF）可能通过抑制肝脏炎症，诱导活化的HSC凋亡，进而减缓肝纤维化的进展，其作用机制可能包括NGF及其低亲和力受体P75的作用。诱导活化HSC凋亡将是治疗和逆转肝纤维化的理想途径。Activation of hepatic stellate cell （HSC）is the critical factor in hepatic fibrosis emerged. Recently, the research has displayed that nerve grouth foctor（NGF） may inhibit liver inflammation to induce apoptosis of activated HSC and to slow down the progress of hepatic fibrosis. The mechanisms may include the effect of NGF and P75. It is an effectual path to treat and reverse hepatic fibrosis inducing apoptosis of activated HSC.

关 键 词：神经生长因子 肝 纤维化 

分 类 号：R575.2[医药卫生—消化系统] R651.3[医药卫生—内科学]