组织工程血管的种子细胞  

Seed cells for tissue engineered vessels

作　　者：孙阳[1] 郭树忠[1] 

机构地区：[1]解放军第四军医大学西京医院整形外科,陕西省西安市710032

出　　处：《中国组织工程研究与临床康复》2008年第51期10175-10178,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：血管移植物数量和功能的不足制约着许多疾病的治疗,因此组织工程血管成为研究的热点。种子细胞作为组织工程血管重要组成部分,如何达到正常血管内皮细胞及平滑肌细胞的生理功能,是人们关注的焦点。干细胞因具备多向分化潜能,被视为理想的种子细胞,然而干细胞种类较多,在组织工程血管的构建过程中,哪种干细胞更适合作为种子细胞,尚无定论。文章对造血干细胞、骨髓间充质干细胞、脂肪干细胞等多种干细胞进行比较,简述各自的特点,试图全面了解干细胞的功能,为进一步实验奠定一定的基础。The quantity or function deficiency of blood vessel grafts hinders many diseases from proper treatment, so tissue engineered blood vessels have gained high attentions. As a crucial component of the tissue engineered blood vessels, how the seed cells can obtain the physiological functions as normal endothelial cells and smooth muscle cells has been focused on. Stem cells are multi-potential and are regarded as proper seed cells. However, it is still a question that which stem cells among a variety of stem cells is the most suitable seed cells for tissue engineered blood vessels. In this review, we make a comparison among kinds of stem cells such as haemopoietic stem cells, bone mesenchymal stem cells and adipose-derived stem cells. We also state their characteristics respectively, and intent to acquaint with their function comprehensively. Thus, this review may provide some references for further studies.

关 键 词：种子细胞 干细胞 组织工程 

分 类 号：R394.2[医药卫生—医学遗传学]