阻塞性黄疸患者肝脏巨噬细胞功能变化的临床研究  

CLINICAL STUDY ON THE CHANGES OF HEPATIC MACROPHAGE FUNCTION IN PATIENTS WITH OBSTRUCTIVE JAUNDICE

作　　者：李智华[1] 韩本立[1] 何振平[1] 刘大平[1] 孙文兵[1] 

机构地区：[1]第三军医大学西南医院

出　　处：《中国普外基础与临床杂志》1998年第2期95-96,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：为探讨阻塞性黄疸患者围手术期感染发生率明显增高的原因，对３６例阻塞性黄疸患者围手术期肝脏Ｋｕｐｆｆｅｒ细胞吞噬功能和血浆内毒素水平变化进行了观察，并与２０例单纯性胆囊结石患者进行比较。结果显示：胆道梗阻后Ｋｕｐｆｅｒ细胞吞噬功能降低，与对照组比较有显著性差异（Ｐ＜０．０５）；血浆内毒素含量升高，与对照组比较有高度显著性差异（Ｐ＜０．０１）。经手术胆道引流后，血浆内毒素水平则逐渐降低。随着Ｋｕｐｆｅｒ细胞吞噬功能恢复，血浆内毒素进一步降低。由此表明，胆道梗阻后Ｋｕｐｆｅｒ细胞吞噬功能变化与血浆内毒素水平有显著的相关关系。Kupffer cell phagocytic function and plasma endotoxin level in 36 patients with obstructive jaundice were observed. The results indicated that kupffer cell phagocytic function was inhibited and the plasma endotoxemia level was markedly increased as compared with those in the control group P <0.05 and P <0.01 respectively. Kupffer cell phagocytic function were recoverd and plasma endotoxemia alleviated while the biliary obstruction was released by surgery.

关 键 词：阻塞性黄疸 内毒素 肝脏 巨噬细胞 

分 类 号：R575[医药卫生—消化系统] R657.4[医药卫生—内科学]