菊苣水提取物干预高嘌呤饮食诱导的鹌鹑尿酸及脂代谢紊乱的实验研究  

Experimental Study of Cichorii Extract Intervening Uric Acid and Lipid Metabolic Disorder of Quail Caused by High-purine Diet

作　　者：杨红莲[1] 张冰[1] 刘小青[1] 林志健[1] 

机构地区：[1]北京中医药大学中药学院,北京100029

出　　处：《中国中医药信息杂志》2009年第1期46-48,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(30472282);北京市自然科学基金(7052036)

摘　　要：目的观察菊苣水提取物对高嘌呤饮食诱导的鹌鹑尿酸(UA)、脂代谢紊乱的影响,并探讨其作用机制。方法鹌鹑按体重随机分为5组:正常组、模型组、阳性药组及菊苣水提取物大、小剂量组,每组15只。正常组给予普通饲料,其余各组均予以造模饲料。阳性药组予苯溴马隆按20mg/(kg·d)灌胃,菊苣水提取物大、小剂量组分别予15、l0g/(kg·d)灌胃,正常组与模型组予等体积蒸馏水灌胃,每日1次。7d后检测UA、三酰甘油(TG)、游离脂肪酸(FFA)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平及尿酸代谢相关酶黄嘌呤氧化酶(XOD)、腺苷脱氨酶(ADA)、鸟嘌呤脱氨酶(GD)活性。结果与正常组比较,模型组UA、TG、FFA显著升高,HDL显著降低;与模型组比较,菊苣水提取物大、小剂量组可显著降低血UA、TG、FFA水平。模型组GD活性较正常组显著升高,菊苣水提取物大、小剂量组可显著降低GD活性;各组XOD与ADA活性比较差异无统计学意义。结论菊苣水提取物具有明显的调节尿酸、脂代谢紊乱的作用,可能的机理是通过降低GD活性而降低UA水平,通过降低UA、FFA水平从而降低TG水平。Objective To observe the influence of Cichorii extract on uric acid and lipid metabolic disorder and discuss the mechanism. Methods Quails were divided randomly into 5 groups by weight： normal group, model group, positive control group and Cichorii extract high and low dosage group, 15 quails in each group. The normal group was fed with the common feeder, and the other groups were fed with the yeast powder. Positive control group was given Benzbromarone 20 mg/（kg · d）. Cichorii extract high and low dosage group were given Cichorii extract 15, 10 g/（kg · d） respectively. Normal and model group were given distilled water. UA, TG, FFA, TC, HDL, LDL level and XOD, ADA, GD activity related to uric acid metabolism were determined after 7 days. Results Compared with normal group, UA, TG, FFA of model group was significantly higher and HDL was significantly lower. Compared with model, Cichorii extract decreased UA, TG, FFA significantly. GD activity in model group increased signifcanfly. Cichorii extract decreased GD activity. There was no significant variance of XOD and ADA activity in each group. Conclusion Cichorii extract had obvious effect in adjusting uric acid and lipid metabolic disorder. The possible mechanism was by decreasing GD activity and decreasing UA, FFA level.

关 键 词：菊苣 高嘌呤饮食 尿酸 脂代谢 鹌鹑 

分 类 号：R285.5[医药卫生—中药学]