慢性脑血管功能不全患者事件相关电位P300的研究  

Study on event-related potential P300 in chronic cerebrovascular insufficiency

作　　者：赵素霞[1] 闫淑静[2] 刘洪雨[1] 张秀明[1] 王慧[1] 张祥建[3] 

机构地区：[1]石家庄市第一医院神经内科,河北石家庄050011 [2]石家庄市第一医院内分泌科,河北石家庄050011 [3]河北医科大学第二医院神经内科,河北石家庄050000

出　　处：《临床荟萃》2009年第1期23-26,共4页Clinical Focus

基　　金：河北省科学技术研究与发展指导计划项目(072761269)

摘　　要：目的探讨慢性脑血管功能不全(CCVI)患者事件相关电位P300及认知功能障碍的特点。方法采用事件相关电位P300、画钟测验(CDT)及简明精神状态量表(MMSE)对CCVI-1型组、CCVI-2型组、CCVI-3型组及正常对照组进行智能检测。结果CCVI-1型组、CCVI-2型组和CCVI-3型组与正常对照组比较,P300波峰潜伏期(P3L)延长,(367.6±16.5)ms、(380.8±29.1)ms、(441.0±42.8)ms vs(351.4±7.4)ms(均P<0.01);P300波幅(Amp)降低,(13.1±6.0)μV、(10.6±5.3)μV、(8.2±4.7)μVvs(16.5±5.4)μV(均P<0.01);CDT评分明显减少,(3.0±0.2)分、(2.4±0.5)分、(1.4±1.0)分vs(3.6±0.5)分(均P<0.01)。CCVI-3型组MMSE评分明显低于正常对照组、CCVI-1型组和CCVI-2型组,(20.7±8.2)分vs(26.3±3.1)分、(25.5±7.8)分、(24.6±7.5)分(P<0.01或<0.05)。CCVI-1型组与正常对照组比较,言语回忆评分显著降低(P<0.01),其余指标差异均无统计学意义(P>0.05);CCVI-2型组与正常对照组、CCVI-1型组比较,注意力计算力、言语回忆和画五角评分显著降低(P<0.01),其余指标差异均无统计学意义(P>0.05);CCVI-3型组与正常对照组、CCVI-1型组及CCVI-2型组比较,注意力计算力、言语回忆、语言重复、写句字和画五角评分显著降低(P<0.01或<0.05),其余指标差异均无统计学意义(P>0.05)。结论CCVI患者存在不同程度的认知功能的障碍,且存在与视觉空间认知有关的执行功能障碍。CCVI-1型的认知功能损害主要累及言语回忆,CCVI-2型的认知功能损害主要累及注意力计算力、言语回忆和画五角,CCVI-3型组的认知功能损害主要累及注意力计算力、言语回忆、语言重复、写句字和画五角。Objective To explore the characters of the event-related potential P300 and cognitive impairment in patients with chronic cerebrovascular insufficiency（CCVI）. Methods Event-related potential P300,clock drawing test （CDT） and mini-mental state examination（MMSE） were used to access the intellectual ability in CCVI-1 group, CCVI-2 group,CCVI-3 group and control group. Results Compared with those of control group the latency of P300 in CCVI-2, CCVI-2,CCVI-3 gruop was significantly, prolonged （367.6 ± 16.5） ms, （380.8± 29.1 ） ms, （441.0 ±42.8 ） ms vs （351.4±7.4） ms （allP 〈0. 01） ,amplitude decreased, （13.1±6.0）μV,（10.6±5.3）μV,（8.2±4.7） μV vs （16.5± 5.4）μV（all P〈0.01） and the scores of CDT reduced,（3.0±0.2） points, （2.4±0.5） points, （1.4±1.0） points vs （3.6±0.5） points （all P〈0.01）. The score of MMSE in CCVI-3 group was significantly lower than that of control group,CCVI-1 group and CCVI-2 group, （20.7 ± 8.2） points vs （26.3± 3.1 ） points, （25.5 ± 7.8） points, （24.6 ± 7.5） points （ P 〈0.01 or 〈0.05）. The scores of recall in CCVI-1 group were significantly low than those in control group（ P〈0.01）, but there were no statistic significances in other scores（ P 〉0.05）. The scores of attention and calculation,recall and construcion in CCVI-2 group were significantly low than those of CCVI-1 and control group （P 〈 0.01）, but there were no statistic significances in other scores （P〉 0.05）. The scores of attention and calculation,recall,language repeat, writing a complete sentence and construction in CCVI-3 group were significantly lower than those of CCVI-1, CCVI-2 and normal control group （ P 〈 0.01 or 〈 0.05）, but there were no statistic significances in other scores（ P〉0.05）. Conclusion The patients of CCVI have not only various degrees of cognitive impairment,but also the disorder of executive function which connects with visual trabecular spaces. Reall is the early

关 键 词：脑血管障碍 事件相关电位 P300 认知障碍 

分 类 号：R743[医药卫生—神经病学与精神病学]