内镜下氩离子凝固术、射频联合抑酸治疗Barrett食管上皮的临床观察  

Clinical observation of argon plasma coagulation or radio frequency combining acid suppression in endoscopic treatment of Barrett esophagus

作　　者：代军 唐佳新[2] 谢宁[3] 熊霞林 刘春园 

机构地区：[1]常德市第一中医院内镜室,湖南常德415000 [2]常德市第一人民医院消化内科,湖南常德415000 [3]中南大学湘雅医学院附属二医院消化内科,湖南长沙410011

出　　处：《临床荟萃》2009年第2期120-122,共3页Clinical Focus

摘　　要：目的观察内镜下氩离子凝固术(APC)、射频治疗术(RF)联合奥美拉唑治疗Barrett食管(BE)上皮的临床效果。方法选择经胃镜和病理证实的BE患者23例,分别行APC或RF,并于术后给予抗反流和抑酸剂治疗。分别于术后1个月、治疗结束后第3、6、12个月进行复查,评价其疗效和不良反应。结果所有患者均完成治疗,采用APC治疗的15例患者中有12例首次治疗即全部清除病灶,另外3例经2次治疗病灶亦完全清除;采用射频治疗的8例患者中有3例治疗1次病灶即消失,4例经2次、1例经3次治疗后始见BE完全消除。12个月后复查5例患者复发。结论应用APC、射频联合抑酸剂治疗BE方法简便易行、安全,且APC治疗效果优于RF。Objective To explore the clinical effect of argon plasma coagulation（APC） or radio frequency（RF） combining omeprazole in endoscopic treatment of Barrett esophagus （BE）. Methods Twenty-three patients were diagnosed as BE by gastroscopy and pathology, 15 of them were treated with APC combining acid suppression,the rest were treated with RF combining acid suppression and domperidone. The results were observed by endoscopy and pathology after one month of treatment. All the cases were rechecked in three months, six months and one year after the ending of all treatments to evaluate the clinical effect and adverse reactions. Results Treatments were accomplished in all patients. The eradication was obtained in 12 cases of 15 by only one APC session, 3 cases required two APC sessions;3 in 8 cases who received RF got eradication after one treatment, 4 after two treatments and 1 after three treatments. BE relapsed in 5 patients during 12 months＇ follow-up. Conclusion Using APC or RF combining acid suppression in endoscopic treatment of BE is convenient and safe,moreover,APC is better than RF.

关 键 词：BARRETT食管 胃镜检查 奥美拉唑 

分 类 号：R571[医药卫生—消化系统]