脂多糖结合蛋白研究进展  

Advances in lipopolysaccharide binding protein

作　　者：吴学玲[1] 赵云峰[2] 钱桂生[1] 

机构地区：[1]第三军医大学新桥医院全军呼吸病研究所,重庆400037 [2]东南大学中大医院呼吸内科,南京210009

出　　处：《国际呼吸杂志》2009年第1期39-43,共5页International Journal of Respiration

基　　金：基金项目：国家自然科学基金资助课题（30170366）

摘　　要：脂多糖（1ipopolysaccharide，LPS）又称内毒素，是革兰阴性细菌外膜的主要成分。LPS与急性期蛋白脂多糖结合蛋白（lipopolysaccharide binding protein，LBP）结合，可导致炎症反应失控及免疫防御屏障机能下降，引起全身炎性反应综合征、脓毒性休克、急性肺损伤甚至多器官功能障碍综合征。另有研究表明LBP亦有抗炎作用，LBP发挥不同的作用是由不同的功能位点决定的。因此说LBP在炎症反应中有双韧剑的作用。Lipopolysaccharide（LPS）,also called endotoxin,is the main component of the bacterial cell wall. After its release from bacteria, LPS can bind to a specific binding protein, known as lipopolysaccharide binding protein（LBP）. The amplification of LPS effects mediated by LBP may be detrimental to the host, which results in systemic inflammatory response syndrome,acute lung injury and multiple organ dysfunction syndrome. Another study shows an inhibitory role of high concentrations of LBP in the LPS-induced inflammatory response. The diverse function of LBP is determined by diverse sites. Therefore, LBP is a twoedge sword in inflammatory reaction.

关 键 词：脂多糖 脂多糖结合蛋白 内毒素血症 

分 类 号：R[医药卫生]