Synthesis,Characterization and DNA-Binding Studies of [Ru(bpy)_(2)(PyIP)]^(2+) and [Ru(dmb)_(2)(PyIP)]^(2+)  

[Ru(bpy)_(2)(PyIP)]^(2+)与[Ru(dmb)_(2)(PyIP)]^(2+)的合成及其与DNA相互作用的研究

作　　者：TAN Li-feng XIAO Yue ZHU Wei-guo ZHOU Yuan-qing ZHANG Sheng 谭黎峰;肖玥;朱卫国;周元清;张晟(湘潭大学化学学院,湖南湘潭411105;湘潭大学环境友好化学与应用省部共建教育部重点实验室,湖南湘潭411105)

机构地区：[1]College of Chemistry,Xiangtan University,Xiangian 411105 [2]Key Lab of Environment-friendly Chemistry and Application in Ministry of Education,Xiangtan University,Xiangtan 411105 China

出　　处：《湘潭大学自然科学学报》2008年第4期94-100,共7页Natural Science Journal of Xiangtan University

基　　金：国家自然科学基金资助项目(20571089);湖南省自然科学基金资助项目(06JJ50023);湖南省教育厅科学研究资助项目(08B086)

摘　　要：Two novel polypyridyl{PylP=2-(pyren-1-yl)-lH-imidazo[4,5-f][1,10]phenanthroline,bpy=2,2′-bipyridine,dmb=4,4′-dimethyl-2,2′-bipyridine}ruthenium(Ⅱ)complexes[Ru(bpy)_(2)(PyIP)]^(2+)(1)and[Ru(dmb)_(2)(PyIP)]^(2+)(2)have been synthesized and characterized by elemental analysis,ES-MS and a H NMR spectroscopy.The DNA-binding of these complexes were investigated by spectroscopic methods and viscosity measurements.The experimental results indicate that both complexes 1 and 2 bind to calf thymus DNA in classical intercalation mode,and however,complex 1 intercalated more strongly than complex 2,due to the different ancillary ligands.合成了两种新型钌多吡啶配合物:[Ru(bpy)_(2)(PyIP)]^(2+)(1)和[Ru(dmb)_(2)(PyIP)]^(2+)(2),采用元素分析、电喷雾质谱和1H NMR对其进行了表征.用紫外滴定、荧光滴定以及粘度的方法研究了两配合物与DNA的相互作用.实验结果表明,两种配合物均以插入方式与DNA结合,然而配合物1与DNA的结合比配合物2的要大.这种现象是由于辅助配体的不同而引起的.

关 键 词：Ruthenium(Ⅱ)complexes DNA-BINDING 

分 类 号：O612.2[理学—无机化学]