贝毒新成员--Azaspiracid shellfish poison  

A new category of shellfish toxins—azaspiracid shellfish poison

作　　者：陈应华[1,2] 杨宇峰[1] 王华接[2] 

机构地区：[1]暨南大学水生生物研究所,广东广州510632 [2]广东省海洋与渔业环境监测中心,广东广州510220

出　　处：《海洋环境科学》2008年第6期677-680,共4页Marine Environmental Science

基　　金：国家自然科学基金委-广东省联合基金(U0633006);国家自然科学基金(40673062)

摘　　要：近年来,欧洲沿海国家发生了一系列因食用紫贻贝(Mytilus edulis)而引起人员中毒的事件。采用适宜的化学提取方法从养殖贝类的组织中提取出了azaspiracid(AZA1)及其类似物,并从养殖海区采集的厚甲原多甲藻(Protoperidinium cras-sipes)细胞中提取出了AZA1、AZA2和AZA3三种成分。鉴于这类毒素(AZAs)具有独特的化学结构和特性,把由它们引起的人员中毒事件称为AZP(azaspiracid shellfish poisoning)。根据近年来国外对AZP研究的最新进展,本文对AZAs的化学结构、来源、地理分布、毒性效应、检测方法及作用机制等方面进行了综述,并对我国开展AZP研究的重点领域提出了建议。Azaspiracid shellfish poison （AZP）, a new human toxic syndrome, was initially reported in the Netherlands in 1995 following the consumption of cultivated blue mussels （Mytilas edulis ） from the west coast of Ireland. Subsequently it reoccurred in northwest Ireland, France, Italy and England. Azaspiracid toxins （AZAs） which are responsible for a series of human intoxications in northern Europe have recently been identified. The major causative toxin, azaspiracid （AZA1）, and its analogues were isolated and structurally elucidated. The potential widespread distribution of azaspiracids in northern Europe was recently confirmed with the identification of these toxins in cultivated shellfish in England, Norway, France and Spain. In this paper, the chemical structures and properties, source, geographical distribution, toxic effects, biological and chemical analysis methods, and mechanism of action of AZAs were reviewed. Some constructive recommendations on the study field of AZP in China were also proposed.

关 键 词：AZA1 AZAs AZP 紫贻贝 原多甲藻 

分 类 号：Q936[生物学—微生物学]