环氧合酶-2在骨肉瘤中的表达与预后的关系  

Expression of COX-2 Protein and Prognosis Significance in Human Osteosarcoma

作　　者：王宪斌[1] 苏利国[1] 张晓军[1] 樊利军[1] 张娉霞 

机构地区：[1]河北省邯郸市第二医院骨科,056001

出　　处：《中华临床医学杂志》2008年第12期19-20,共2页Chinese Journal of Clinical Practical Medicine

摘　　要：目的探讨骨肉瘤中COX-2的表达水平同预后的关系。方法应用免疫组化方法对60例骨肉瘤患者术后标本进行染色，检测COX-2的表达情况，以2年的随诊情况为基准，其中术后2年死亡的为30例，30例未死亡。比较两者之间的差异性。结果COX-2在骨肉瘤中的总阳性率为80．0％，其中2年内死亡的阳性率为96．7％，未死亡的为63．3％，通过X^2检验，P〈O．05。两者之间存在显著的差异。结论临床上应用免疫组化进行COX-2的检测可能成为评价骨肉瘤预后的一项重要指标。Objective To investigate the expression of COX-2 in human osteosarcoma and the relationship between expression of COX-2 and prognosis in human osteosarcoma.Methods 60 patients who underwent surgical resection during 1994 and 2004 were followed up.expression of COX-2 were examined by s-p immunohistoche- mistry in 60 archival paraffin-embedded tissue specimens. Results COX-2 expression rates of them were 96.7% and 63.3% respectively. Analysis of survival data showed that patients with positive reaction for COX-2 had lower survival rate and poorer prognosis. Conclusion Detection of COX-2 can be used to predict recurrence of the tumor and also valuable in evaluating the prognosis of osteosarcoma.

关 键 词：骨肉瘤 环氧合酶-2 免疫组织化学 预后 

分 类 号：R730.5[医药卫生—肿瘤]