563例鼻咽癌腔内残留病灶后装放疗的近期和远期疗效  

Short and long term therapeutic effects of brachytherapy on intracavitary residual tumor in 563 nasopharyngeal carcinoma (NPC) patients

作　　者：曹新平[1] 陈昆田[1] 何志纯 张万团[1] 

机构地区：[1]中山医科大学肿瘤防治中心

出　　处：《中华肿瘤杂志》1998年第2期146-147,共2页Chinese Journal of Oncology

摘　　要：目的评价后装腔内放疗对鼻咽癌外照射后腔内残留病灶的疗效。方法回顾性总结５６３例高剂量率后装放疗，对鼻咽癌外照射后鼻咽腔粘膜残留病灶的疗效。后装放疗剂量２０～２５Ｇｙ。结果近期３个月鼻咽腔残留肿物的消退率为９０．４％。其中３８７例随诊已超过３年。其１，３，５年生存率分别为８９．６％、６７．０％、５５．４％。比较突出的副作用为鼻塞，发生率为１６．２％。其余副作用未有明显增加。结论后装放疗对鼻咽腔内残留病灶有较好疗效，特别是对分期较早的患者，但是对于ＩＶ期患者不一定有帮助。Objective To evaluates the effect of brachytherapy on intracavitary residual tumor in patients with NPC after external radiation therapy. Methods Five hundred fifty three NPC patients with residual tumor in the nasopharynx were treated with large dose brachytherapy (20 25Gy). The treatment results were retrospectively evaluated. Results Within 3 months after brachytherapy, the overall regression rate of the residual tumor was 90.4%. Upon long term follow up,the 1 , 3 , and 5 year survival rate was 89.6%, 67.0% and 55.4%, respectively. The major complications of the after loading treatment were nasal obstruction (16.2%), necrosis of the naso pharynx (0.9%) and perforation of soft palate in 2 patients. Conclusion Brachytherapy is effective in the treatment of residual NPC especially in patients in early stage. It may not be helpful for stage IV patients.

关 键 词：鼻咽肿瘤 放射疗法 近距离治疗 

分 类 号：R739.630.5[医药卫生—肿瘤]