神经前体细胞在中枢神经系统基因治疗中的应用  

Application of neural progenitor cell in genc therapy for central nervous system diseases

作　　者：高峰[1] 田玉科[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉科,武汉430030

出　　处：《国际麻醉学与复苏杂志》2008年第6期537-539,543,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基因资助项目（30170905）

摘　　要：基因治疗有望为中枢神经系统疾病提供一种有效的治疗手段，神经前体细胞由于其良好的生物学特性，因此目前被认为是中枢神经系统转基因治疗较为理想的载体细胞。现仅针对神经前体细胞在中枢神经系统基因治疗中的研究进展作一综述。Gene therapy may provide an effective and hopeful method for the therapy of central nervous system diseases. Neural progenitor cell （NPC） is a kind of cells with the capability of proliferation, self-renewal and muhi-differentiation. Their ability to widely migrate throughout the brain tissue after transplantation, and to integrate in a functional and non-disruptive manner makes them an ideal cell vehicle choice for gene transfer to central nervous system. The application of neural progenitor cell in gene therapy for central nervous system diseases is reviewed in this article.

关 键 词：神经前体细胞 基因治疗 细胞移植 中枢神经系统 

分 类 号：R741[医药卫生—神经病学与精神病学] R338[医药卫生—临床医学]