C12多肿瘤标志物检测系统在结直肠癌诊断中的价值  

Value of C12 tumor markers protein chip in diagnosis of colorectal cancer

作　　者：杨雪琴[1] 陈创[2] 侯晋轩[2] 杨国梁[2] 李雁[2] 

机构地区：[1]荆楚理工学院医学院,湖北荆门448000 [2]武汉大学中南医院肿瘤科,肿瘤生物学行为湖北省重点实验室

出　　处：《江苏医药》2009年第1期5-7,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金资助项目(20675058);荆门市科技计划项目(08812);武汉市创新研究课题资助(2006002054)

摘　　要：目的探讨C12蛋白芯片系统在结直肠癌(CRC)诊断中的价值。方法分析173例CRC初治病人12种肿瘤标志物(TM)的检测结果,找出与CRC相关性最强的TM,计算不同TM组合方式提高诊断率的效果。结果C12对本组CRC病人的总诊断率是42.20%;Ⅰ、Ⅱ、Ⅲ和Ⅳ期病人的诊断率分别是12.90%、38.46%、40.91%和70.27%,整体差异明显(P<0.01)。CEA的阳性率最高,为36.42%。与之相比,该C12蛋白芯片系统中任何组合方式(2、3、4、5、12种TM组合)均不能提高诊断率。但男性患者的4项TM联合(CEA+Fr-PSA+CA125+CA242/CA19-9)和女性患者的三项TM联合(CEA+CA125+CA242/CA19-9)的CRC检测价值足以替代12项TM联合检测。结论C12对诊断中晚期CRC有一定价值,但对早期CRC的灵敏度不高。Objective To evaluate the value of C12 protein chip system in the diagnosis of colorectal cancer （CRC）. Methods The results of serum examination from 173 patients with pathology-confirmed CRC were analyzed by the C12 protein chip system, by which the most relevant tumor markers and the contribution of various combinations of tumor markers for improving the diagnosis were determined. Results The total diagnostic rate of C12 biochip system for CRC in 173 patients was 42.20%. The diagnostic rates of stages Ⅰ , Ⅱ , Ⅲand Ⅳwere 12. 90%, 38.46%, 40. 91% and 70. 27%, respectively. The differences in diagnostic rates among clinical stages were statistically significant （P〈0. 01）. The highest positive rate（36.42%） for CRC diagnosis was found with CEA detection. Any form of combinations of TM in C12 system could not significantly improve the diagnostic rate. The combination of 4 TMs （CEA ＋ Fr-PSA ＋ CA125 ＋ CA242/CA19-9） for male patients,and of 3 TMs （CEA ＋ CA125 ＋ CA242/CA19-9） for female could replace 12 TMs of C12 biochip system. Conclusion The C12 protein chip diagnosis system has certain value in the diagnosis of advanced CRC, but the sensitivity for early CRC is not satisfactory.

关 键 词：结直肠癌 肿瘤标志物 蛋白芯片 

分 类 号：R730[医药卫生—肿瘤]