C-erbB-2和EGFR在胃癌中的表达  

Expression of C-erbB-2 and EGFR in gastric cancer

作　　者：凌斌勋[1] 陈环球[1] 徐新宇[1] 周兆飞[1] 陆建伟[1] 

机构地区：[1]江苏省肿瘤医院内科,南京210009

出　　处：《江苏医药》2009年第1期17-19,共3页Jiangsu Medical Journal

基　　金：江苏省人事厅六大人才高峰项目(07-B-024);江苏省社会发展科技计划项目基金(BS2007010)

摘　　要：目的探讨C-erbB-2和表皮生长因子受体(EGFR)与胃癌临床病理特征的关系。方法用免疫组织化学法对胃癌手术切除瘤组织检测C-erbB-2和EGFR表达。结果C-erbB-2表达阳性率为6.73%(14/209),其表达与年龄、病变部位、病理类型、分化程度等密切相关(P<0.05);EGFR表达阳性率为40.67%(85/209),其表达与年龄密切相关(P<0.01),与其他病理因素均无明显关系(P>0.05);C-erbB-2和EGFR表达无明显关系(P>0.05)。结论C-erbB-2的表达与胃癌的生物学行为有一定的相关性,但与EGFR表达无明显关系。Objective To study the relationship between the expressions of C-erbB-2 and epidermal growth factor receptor （EGFR） with pathological behaviors of gastric cancer. Methods The expressions of C-erbB-2 and EGFR in tumor biopsy specimens from patients with gastric cancer were detected by immunohistochemistry. Results The positive rate of C-erbB-2 expression was 6. 73 % （14 / 209）, which was closely correlated with age, site of tumor, pathology type and degree of differentiation （P〈0.05）. The positive rate of EGFR expression was 40. 67%（85 of 209） ,which was closely correlated with age （P〈0. 01）, but not with the other pathological behaviors of gastric cancer （P〉0. 05）. There was no significant correlation between the expression of C-erbB-2 and EGFR （P〉 0.05）. Conclusion The expression of C-erbB-2 has a close relationship with biological behaviors of human gastric cancer, but has no relationship with EGFR.

关 键 词：胃癌 C-ERBB-2 表皮生长因子受体 

分 类 号：R735[医药卫生—肿瘤]