PPI试验对糜烂性食管炎的诊断价值  

Significance of PPI test in diagnosing erosive esophagitis

作　　者：王莉[1] 邹晓平[1] 曹俊[1] 

机构地区：[1]南京大学医学院附属鼓楼医院消化病科,210008

出　　处：《江苏医药》2009年第1期66-67,共2页Jiangsu Medical Journal

摘　　要：目的比较奥美拉唑和雷贝拉唑对糜烂性食管炎患者短期临床效果,并探讨两者作为质子泵抑制剂(PPI)试验的诊断价值。方法选择临床有烧心、反酸、胸骨后灼痛等反流症状,且胃镜检查确诊为糜烂性食管炎的患者63例,随机分别给予奥美拉唑20mg,每天2次(A组,31例)或雷贝拉唑10mg,每天2次(B组,32例)口服1周。以反流的相关症状下降2个等级或由轻度降为无症状为PPI试验阳性作为诊断标准,第3天和第7天进行症状评分及统计学分析。结果治疗第3天B组症状评分明显低于A组(P<0.01)。A组第3天检出率明显低于B组(48.4%vs.87.5%)(P<0.01)。结论与奥美拉唑相比,临床短期给雷贝拉唑能够更加迅速缓解糜烂性食管炎症状,雷贝拉唑试验可以改良传统的奥美拉唑试验。Objective To compaere the short term clinical effects of the proton pump inhibitor （PPI） rabeprazole and omeprazole on the patients with erosive esophagitis and evaluate the diagnostic values of PPI test. Methods A total of 63 cases with the refluxing symptoms and the diagnose of erosive esophagitis by electronic gastroscopy were randomly divided into two groups. The patients were given omeprazole 20 mg,bid（group A,31 cases）, or rabeprazole 10 mg,bid（group B, 32 cases）, respectively, for one week. The positive detection was defined as two grades decrease of clinical symotomes or the change of the symotomes from mild to disappearance. The refluxing symptoms were evaluated and analyzed on the 3^rd and 7^th day of the treatment course. Results The symptom score of group B was significantly lower than that of group A on the 3^rd day of treatment （P〈0. 01 ）. Detection rate on the 3^rd day was significantly lower in group A than that in group B（48. 4% vs. 87.5%）（P〈0. 01）. Conclusion Compared With omeprazole, rabeprazole has more potent and rapid onset of relieving refluxing symptoms after short term clinical treatment. The rabeprazole test can be used to upgrade the traditional omeprazole test.

关 键 词：雷贝拉唑 质子泵抑制剂试验 糜烂性食管炎 

分 类 号：R730[医药卫生—肿瘤]