p27在乳腺癌中的表达与意义  

Expression and significance of p27 in breast cancer

作　　者：蔡瑜娇[1] 马小干[1] 王亚丽[2] 刘玲[1] 

机构地区：[1]第三军医大学新桥医院普通外科,重庆400037 [2]第三军医大学新桥医院病理科,重庆400037

出　　处：《重庆医学》2009年第1期56-57,59,共3页Chongqing medicine

基　　金：第三军医大学校管课题资助项目(2006D144)

摘　　要：目的探讨p27在乳腺癌中的表达及意义。方法采用免疫组织化学及原位杂交的方法检测27例乳腺纤维腺瘤、56例乳腺癌组织p27在mRNA及蛋白水平的表达,分析其与临床病理特征的关系,并探讨p27在乳腺癌组织中低表达的原因。结果p27低表达率为55.0%(31/56),p27的低表达与乳腺肿瘤大小、淋巴结转移、组织学分级及Her-2表达有关(P<0.01)。结论p27低表达是乳腺癌高度恶性和预后不良的生物学指标,p27甲基化可能是其在乳腺癌中低表达的原因。Objective To investigate the expression and significance of p27 in breast cancer. Methods To analyze the correlation of the expression of p27 and the clinicopathologie features in breast cancer by methods immunohistochemical staining and hybridization in situ which were performed to examine the expression of p27 at proteinum and mRNA level in 27 specimens of fibroadenoma and 56 specimens of breast breast cancer. Results The low p27 expression rate was 55.0%（31/56） ,low expression in breast cancer was associated with larger tumor,lymph node metastasis, histological grade and expression of Her-2（P〈0.01）. Conclusion Low p27 expression is important factor to high malignancy and poor prognosis in breast cancer,which might be regulated by methylation in p27 expression.

关 键 词：乳腺癌 P27 病理 免疫组织化学 原位杂交 

分 类 号：R737.9[医药卫生—肿瘤] R730.21[医药卫生—临床医学]