原发性胆囊癌预后影响因素分析  

Prognostic Factors for Primary Carcinoma of the Gallbladder

作　　者：戴赛民[1] 郑纪虎[1] 郭子健[1] 张勇[1] 周鹏[1] 周俊晶[1] 

机构地区：[1]江苏省无锡市第四人民医院肝胆外科,江苏无锡214062

出　　处：《中国临床医学》2008年第6期805-806,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨影响原发性胆囊癌(pri mary carcinoma of the gallbladder,PCG)患者的预后相关因素。方法:对2004年-2007年诊治27例原发性胆囊癌患者的临床、病理资料进行回顾分析,Kaplan-Meier法比较各组间的生存率,COX比例风险模型分析各因素对预后的影响。结果:单因素分析表明CEA、CA19-9、Nevin分期、治疗方法与PCG患者的预后有关。胆囊癌单纯切除组和根治组与姑息手术组、剖腹探查组、非手术组间有显著差异。COX比例风险模型分析表明CEA、CA19-9、Nevin分期、手术治疗4个因素与PCG生存时间显著相关,其中Nevin分期、手术治疗风险比最高。结论:CEA、CA19-9、Nevin分期、手术方式为PCG患者独立影响因素。Objective：To investigate prognostic factors for primary carcinoma of the gallbladder （PCG）. Methods：From 2004 to 2007, 23 patients with primary carcinoma of the gallbladder were treated and eligible for the analysis. Kaplan Meier survival a nalysis and Cox proportional hazard model were used to analyze the relationship between the prognostic factors and survival time. Results： Kaplan Meier analysis showed that CEA, CA19-9, Nevin stage, surgical treatment were related to prognosis. Simple and radical resection for gallbladder cancer were statistical difference compared with palliative resection and biopsy（P〈0. 05）. Cox regression model indicated that CEA, CA19-9, Nevin stage, surgical treatment were related to PCG survival time. Conclusion： CEA,CA19-9, Nevin stage, surgical prognosis were independent prognostic factors of PCG patients.

关 键 词：原发性胆囊癌 预后 生存分析 

分 类 号：R735.8[医药卫生—肿瘤]