谷胱甘肽转移酶μ基因多态性与帕金森病的关系  

Glutathione S transferase μ polymorphism in Parkinson's disease.

作　　者：陶恩祥[1,2,1] 刘焯霖[1,2,1] 潘锡榜[1,2,1] 邵明 

机构地区：[1]中山医科大学第一附属医院神经科 [2]中山医科大学孙逸仙纪念医院神经科

出　　处：《中国神经精神疾病杂志》1998年第2期79-80,共2页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的为了研究机体解毒系统的障碍在帕金森病（ＰＤ）遗传易感性中的作用。方法选择确诊的ＰＤ病人和年龄、性别基本匹配的正常人各１００名，分离白细胞ＤＮＡ，利用聚合酶链反应检测解毒酶谷胱甘肽转移酶μ（ＧＳＴＭ）基因突变率，并分析比较ＰＤ病人与正常人之间多态性频率的差异。结果发现ＧＳＴＭ无效基因（ＧＳＴＭ０型）使患ＰＤ的危险性提高１５３倍。结论提示解毒酶ＧＳＴＭ０基因缺陷可能是ＰＤ遗传易感性的一个原因。Objective In order to study the role of the defect of xenobiotic metabolizing enzymes in the gentic susceptibility of Parkinson's disease. Methods Gene polymorphism of glutathione S-transferase μ (GSTM) was studied with polymerase chain reaction method in 100 cases of Parkinson's disease and 100 age and sex matched control individuals and compared the frequencies of the allele between the two groups. Results It was shown that the frequencies of the GSTM0 allele in the patient group was a little higher than that of the controls, and the GSTM0 allele increased the risk ratio of PD 1.53 fold higher. Conclusions It was suggested that the detoxining enzyme GSTM gene mutation might be one risk factor of the genetic susceptibility of Parkinsons disease.

关 键 词：震颤性麻痹 药物疗法 谷胱甘肽转移酶 

分 类 号：R742.505[医药卫生—神经病学与精神病学]