阿泰宁(酪酸梭菌胶囊)治疗慢性结直肠炎的疗效观察  

The therapeutic effects of Ataining on chronic colitis

作　　者：宋捷[1] 彭丽花[1] 张敏[1] 聂昭华[1] 温静[1] 万阜昌 李洪福 崔云龙 

机构地区：[1]解放军第261医院消化科,北京100094 [2]青岛市微生态工程技术研究中心,山东青岛266400

出　　处：《中国微生态学杂志》2009年第1期60-62,共3页Chinese Journal of Microecology

摘　　要：目的通过临床治疗评价阿泰宁对未确定型结肠炎(IC)和溃疡性结肠炎(UC)的疗效,探讨治疗该病的新方法。方法选择21例IC和UC患者,其中UC诊断参考中华医学会消化病分会炎症性肠病协作组提出的炎症性肠病诊断标准,给予阿泰宁口服,1次3粒,1天3次,连用4～8周。观察治疗期间的临床症状改善情况和治疗结束时进行结肠镜复查并判定其疗效。结果患者的腹泻次数由治疗前(3.60±0.94)次/d,减少到(1.5±0.71)次/d(P<0.001);异常便(黏液便、脓血便等)由100%下降为9.5%;腹痛由90.5%下降至14.3%;里急后重由66.7%下降至9.5%。结肠镜查,黏膜基本愈合者10例(47.6%),黏膜炎症有改善者8例(38.1%),无改善者3例(14.3%)。临床疗效,完全缓解10例(47.6%);有效8例(38.1%);无效3例(14.3%),总有效率为85.7%。12例确诊UC患者中完全缓解6例(50%),有效4例(33.3%),无效2例(16.7),总有效率为83.3%。结论阿泰宁对IC和UC患者有较好的治疗效果,能明显地改善临床症状和促进受损的肠黏膜愈合,值得推广应用。Objective To evaluate the therapeutic effect of Ataining through the clinical treatment of IC and UC to find a new way to treat these diseases. Methods 21 cases of patients with IC and UC （ the diagnosis of UC was according to the UC diagnostic criteria of Cooperative Group of Gastroenterology Branch of the Chinese Medical Association） were chosen and treated with Ataining,three capsules each time and three times daily for 4 -8 weeks. The improvement of their symptoms during treatment were observed and the therapeutic effect after treatment was evaluated by colonoscope rechecking. Results The diarrhea frequency of patients were reduced significantly from （ 3.60±0.94 ） times/d before treatment to （ 1.5 ± 0.71 ） times/d after treatment （ P 〈 0. 001 ） ; mucus stool and bloody stool were reduced significantly from 100% to 9.5% ;abdominal pain was relieved from 90.5% to 14.3% and tenesmus from 66.7% to 9.5%. According to the results of colonofiberscopic examination, there were 10 cases had mueosal healing （47.6%） ;8 eases got improved in mucosa （38. 1% ） ;while 3 cases had no changes （ 14.3% ）. The total effective rate was 85.7% , with 10 cases of complete remission （47.6%） ,8 cases had effective （ 38.1% ） , and 3 cases ineffective （ 14.3% ）. In 12 cases of UC, there were 6 cases of complete remission （50%） ,4 cases effective （33.3%） ,2 cases ineffective （ 16.7% ） ;the total effective rate was 83.3%. Conclusion Ataining had considerable therapeutic effects on IC and UC. It could improve clinical symptoms of UC and restore the scathed intestinal mucosa.

关 键 词：阿泰宁 酪酸梭菌 未确定型结肠炎 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]