胃肠恶性间质瘤27例诊治分析  

The diagnosis and treatment of malignant gastrointestinal stromal tumor： report of 27 cases

作　　者：马金生[1] 井小会[1] 

机构地区：[1]河南省平顶山市第一人民医院普外科,467000

出　　处：《中国实用医刊》2009年第2期42-43,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨胃肠恶性间质瘤的诊治方法。方法回顾性分析我院1999年9月至2008年6月收治的胃肠恶性间质瘤27例的临床及病理资料。结果本组27例均行手术治疗。肿瘤根治5例，近端或远端胃大部切除、病变肠段切除、肿块切除或扩大切除16例；因肿瘤广泛粘连，无法完整切除6例。术后病理免疫组化CD117阳性24例，CD34阳性19例。结论胃肠恶性间质瘤在中老年人中好发，以便血、腹痛和腹部不适、腹部肿块表现为主。病理检查是确诊恶性间质瘤的惟一方法。完整的局部手术切除是最有效的治疗手段。对无法切除或有肿瘤残余及术后复发的病人可应用格列卫进行治疗。Objective To study the diagnosis and treatment of malignant gastrointestinal stromal tumor（GIST）. Methods Clinical and pathological data of 27 cases of malignant GIST at our hospital from Sep. 1999 to Jun. 2008 were retrospectively analyzed. Results All patients underwent operation. Five cases were treated with radical surgery, sixteen cases with proximal or distal gastrectomy, partial intestine resection, tumor ectomy or wide local excision. The other six cases received palliative resection because of locally invasire disease. Immunohistochemical results showed CD117（ ＋ ） in twenty -four cases, CD34（ ＋ ） in nineteen cases. Conclusions Malignant GIST occurred in aged patients frequently with clinical manifestation of gastrointestinal bleeding, abdominal pain or discomfort and abdominalmass. Pathological examination is annique method for diagnosis of GIST. Total resection of the tumor is the most effective measure for the patients. Glivec is beneficial to the terminal stage patients with unreestable, residual or recurrent tumor.

关 键 词：胃肠恶性间质瘤 诊断 治疗 

分 类 号：R735[医药卫生—肿瘤]