大麻CB_2受体在中枢神经系统的分布及其激动剂的药理作用  

Expression of Cannabinoid receptor 2 in the CNS and pharmacology of its agonists

作　　者：李素燕[1] 颜玲娣[1] 宫泽辉[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学通报》2009年第1期5-8,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30600761)

摘　　要：大麻受体分为大麻受体1(CB1)和大麻受体2(CB2),CB2受体主要分布于外周免疫系统,目前研究发现其在中枢神经系统(CNS)也有少量的分布,这可能与其中枢作用密切相关。已有文献报道CB2受体激动剂具有抑制疼痛产生和持续及神经退行性病变等药理学特性,且长期给药不产生明显的精神和躯体依赖等副作用,显示出良好的临床应用前景。为了更好地认识、研究和利用CB2受体及其激动剂,该文综述了CB2受体在CNS的分布及其药理作用特点。Two types of cannabinoid receptors, named cannabi- noid receptor 1 （CB1） and cannabinoid receptor 2 （ CB2 ） , have been cloned. CB2 receptors are expressed predominantly in the peripheral immune tissues, but accumulating evidence has revealed that CB2 receptors are also expressed in CNS. Previous studies showed that CB2 agonists can cure and suppress formation of inflammatory and neurophathic pain without central effects after chronic administration. Therefore, they will have good clinical applications in the treatment of pain and neurodegenerative diseases. In this paper, we will review the tissue distribution of CB2 in CNS and pharmacological characteristics of the CB2 agonists have been reviewed.

关 键 词：大麻受体2 组织分布 中枢神经系统 CB2受体激动 剂 神经源性疼痛 

分 类 号：R-05[医药卫生] R322.81