细胞缝隙连接与HSV-TK/GCV系统旁观者效应的关系  

The relationship of gap junction with the bystander effect in the HSV-TK/GCV treatment

作　　者：杨燕[1] 陶亮[1] 

机构地区：[1]中山大学中山医学院药理学教研室,广东广州510080

出　　处：《中国药理学通报》2009年第1期9-12,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30672412)

摘　　要：在用单纯疱疹病毒胸苷激酶/丙氧鸟苷(HSV-TK/GCV)自杀基因系统治疗肿瘤的研究中,一个有趣和重要的现象就是旁观者效应(bystander effect,BE)。它在很大程度上提高了HSV-TK/GCV系统治疗肿瘤的疗效。但到目前为止,BE的确切机制尚未阐明。大量研究表明,靶细胞连接蛋白(connexin,Cx)的表达及其形成的细胞间缝隙连接(gapjunction,GJ)与这一现象关系密切。该文对GJ与HSV-TK/GCV系统BE的关系作一综述,并探讨了由HSV-TK/GCV系统生成可经GJ传递的"死亡信号"的性质。The bystander effect （BE） plays an important role in the gene therapy of cancer by the herpes thymidine kinase/gan- ciclovir （HSV-TK/GCV） system. It enhances the therapeutic ef- ficacy of this system. Up to now, the exact underlying mechanism of the bystander effect remains unclear. A large body of evidence has indicated a close correlation of the connexin expression and gap junction in the targeted cells to the bystander effect. Here the publications concerning the relationship of gap junction with the bystander effect in the HSV-TK/GCV treatment have been re- viewed. The possible cell death signals that can be transferred through gap junction to induce the bystander effect are also discussed.

关 键 词：连接蛋白 缝隙连接 旁观者效应 HSV—TK/GCV系统 自杀基因疗法 

分 类 号：R-05[医药卫生] R329