GSTM1基因多态性与肿瘤遗传易感性研究进展  

The study of GSTM1 genetic polymorphisms and tumor hereditary susceptibility

作　　者：杨志国[1] 谢裕安[1] 

机构地区：[1]广西医科大学肿瘤医院,广西南宁530021

出　　处：《现代肿瘤医学》2009年第1期138-141,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(30660204);广西研究生教育创新计划基金(2007105981002M26)

摘　　要：谷胱甘肽转硫酶(glutathione S-tranferase,GSTs)是一组具有多种生理功能的蛋白质,是与毒物或致癌物的解毒代谢有关的酶类,在机体代谢有毒化合物、保护细胞免受急性毒性化学物质攻击和抑制细胞癌变中起着重要的作用。因此,编码GSTs的GSTM1基因成为近年来研究的热点。最近国内外众多关于GSTM1基因多态性与肿瘤易感性关联的病例对照研究,均提示GSTM1单核苷酸多态性与多个肿瘤的易感性有关。Glutathione S - tranferase（GSTs） is a group of protein with multi - physiological functions ,which is also a kind of metabolizing enzymes associated with detoxifying some poison and carcinogens. It plays an important role in protecting the cells from attacking by the acute chemical toxic materials and inhibiting eancerization of cells. Thus, GSTM1 gene coding GSTs becomes the hot spot in current studies. Recently,the most foreign and native case -control researches,with regard to the relation between GSTM1 genetic polymorphisms and the tumor susceptibility, clue to that there are some relationship between them.

关 键 词：GSTM1 基因多态性 遗传易感性 肿瘤 

分 类 号：R730.3[医药卫生—肿瘤]