恶性黑素瘤与磷脂酰肌醇3-激酶-Akt信号通路  

Phosphatidylinositol-3-kinase-Akt signaling pathway in malignant melanoma

作　　者：杨凌云[1] 黄长征[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,武汉430030

出　　处：《国际皮肤性病学杂志》2009年第1期21-23,共3页International Journal of Dermatology and Venereology

基　　金：基金项目：国家自然科学基金（30671691）

摘　　要：磷脂酰肌醇3-激酶信号参与增殖、分化、凋亡和葡萄糖转运等多种细胞功能的调节。近年来发现，IA型磷脂酰肌醇3-激酶和其下游分子蛋白激酶B所组成的信号通路与人类恶性黑素瘤的发生发展密切相关。该通路调节黑素瘤细胞的增殖和存活，其活性异常不但能引起细胞恶性转化，而且与黑素瘤细胞的迁移、黏附、血管生成以及细胞外基质的降解等相关。目前以磷脂酰肌醇3-激酶-Akt信号通路关键分子为靶点的恶性黑素瘤治疗策略正在研究中。Phosphatidylinositol-3-kinase （PI3K） signaling pathway participates in the regulation of many kinds of cell biological behavior, e.g., proliferation, differentiation, apoptosis and transport of glucose. Recently, it has been revealed that the signaling pathway consisting class Ia PI3K and its downstream molecule protein kinase B （PKB/Akt） has a close relationship with the occurrence and development of human malignant melanoma. The pathway can regulate the proliferation and survival of melanoma cells. The abnormality of this pathway can not only cause malignant transformation but also affect the migration, adherence, angiogenesis and extracellular matrix degradation of melanoma cells. Currently, therapeutic strategy targeting the key molecules in PI3K pathway is under research of malignant melanoma.

关 键 词：黑色素瘤 1-磷脂酰肌醇3-激酶 蛋白激酶B 

分 类 号：R739.5[医药卫生—肿瘤]