电针对脑梗死患者血清中谷胱甘肽过氧化物酶活性及谷胱甘肽含量的影响  

Effects of Electroacupuncture on Activity of GSH-Px and Serum Contents of GSH in Patients with Cerebral Infarction

作　　者：湛湘丽[1] 宿宝贵[1] 潘三强[1] 粟漩 吕来清[1] 韩辉[1] 

机构地区：[1]暨南大学医学院人体解剖学教研室,广东广州510562 [2]广东佛山南海区中医院针灸科,广东佛山528200

出　　处：《广州医学院学报》2008年第4期17-19,共3页Academic Journal of Guangzhou Medical College

基　　金：广州巿科技计划项目(2007J1-C0051)

摘　　要：目的:探讨电针对脑梗死患者血清中谷胱甘肽过氧化物酶(GSH-Px)活性及谷胱甘肽(GSH)含量的影响。方法:利用比色法对20例正常人及20例急性脑梗死患者电针治疗前、后血清中GSH含量与GSH-Px活性分别进行测定,并对比分析。结果:急性脑梗死患者电针治疗后血清中GSH含量(11.95±1.67)mg/L、GSH-Px活性(192.49±19.27)IU比治疗前[(2.53±0.84)mg/L,(122.40±24.26)IU]和正常组[(4.98±0.83)mg/L,(144.06±35.07)IU]都显著性增高(P<0.01);电针前与正常组比较,GSH含量、GSH-PX的活性有显著性减低(P<0.01)。结论:电针治疗能提高人体血清中抗氧化剂的含量,对脑梗死患者因氧化应激生成的自由基有一定的清除效应。Objective： To investigate the effects of electroacupuncture （EA） on activity of GSH-Px and serum contents of GSH in patients with cerebral infarction. Methods： Serum levels of GSH-Px and GSH in 20 patients with cerebral ischemia and 20 healthy controls were determined by colorimetry and compared between the two groups. Results： After treatment with electroacupuncture, the serum levels of GSH （11.95±1.67）mg/L and GSH-Px activity （192.49±19.27）IU in the ischemic patients were significantly increased as compared with baseline [（2.53±0.84）mg/L and （122.40±24.26）IU, P〈0.01 ] and with the control group [（4.98±0.83）mg/L and （144.06±35.07）IU, P〈0.01 ]. But GSH-Px activity and GSH content in serum in the pre-EA patients were found to be much lower than those in the control group （P〈0.01）. Conclusion： EA was shown to increase the activities of anti-oxidants in human, which may be useful to scavenge free radicals generated from oxidative stress in patients with cerebral infarction.

关 键 词：脑梗死 谷胱甘肽 谷胱甘肽过氧化物酶 电针 自由基 脑缺血再灌注 脂质过氧化 氧化应激 

分 类 号：R743.33[医药卫生—神经病学与精神病学]