CYP1A1基因多态性与子宫内膜癌易感性关系的研究  

Correlation of CYP1A1 genetic polymorphism with the susceptibility of the endometrial cancer.

作　　者：李凤仙[1] 李利[1] 李琰[1] 王建英[1] 张军[1] 程建新[1] 张宁[1] 

机构地区：[1]河北医科大学第四医院,石家庄050011

出　　处：《现代妇产科进展》2008年第11期820-823,共4页Progress in Obstetrics and Gynecology

基　　金：河北省自然科学基金资助项目(No:C2006000857)

摘　　要：目的:研究细胞色素P4501A1(CYP1A1)基因MspⅠ位点多态性与子宫内膜癌发生的关系。方法:用PCR-RFLP法检测174例子宫内膜腺癌患者和114例对照者CYP1A1基因MspI位点多态性。结果:合并杂合型T/C和突变型C/C后与野生型T/T比较,两组差异有统计学意义(P=0.047,OR=1.635)。在绝经年龄<50岁的病例组,T和C等位基因频率与对照组相比差异有统计学意义(P=0.032);初潮年龄≤14岁,等位基因频率在两组中差异有统计学意义(P=0.036);经BMI分层分析,未发现MspI多态性与子宫内膜癌有关。结论:CYP1A1基因MspI多态中突变等位基因C可显著增加子宫内膜癌的发病风险,且绝经年龄越早、初潮年龄越早携带等位基因C的个体越易感子宫内膜癌。Objective：To investigate the correlation of genetic polymorphisms about cytochrome P4501A1 （CYP1 A1 ） with the susceptibility of the endometrial cancer. Methods：This population-based case-control study, including 174 endometrial cancer patients and 114 healthy controls, tested the genetic polymorphism of CYPIA1 Msp I by PCR- RELP. Results：Contrast with T/T genotype, merging T/C and C/C, the difference between the case and control group was significant（P = 0. 047, OR = 1. 635）. In the patients whose menopause ages were lower than fifty years, there was significant difference between the alleles of the two groups （ P = 0. 032）. There was significant difference between the alleles of the two groups whose menarche age lower than fourteen years （P = 0. 036 ）. According to BMI, no correlation was found between CYP1A1 MspI polymorphism and endometrial cancer. Conclusions：In CYP1A1 Msp I poly- morphism, the C allele can increase the risk of endometrial cancer, and the risk of individual with C allele when menopause age and menarche age were early.

关 键 词：细胞色素P450 CYP1A1基因 基因多态性 子宫内膜肿瘤 

分 类 号：R737.33[医药卫生—肿瘤]