血管生成素-2和内皮抑素在子宫内膜异位症发生发展中的作用  

The effect of angiopoietin-2 and endostatin in genesis and development of endometriosis.

作　　者：范俊[1] 董文韬 孙宝治[1] 栾少红[1] 马慧敏[1] 李晓林[1] 

机构地区：[1]青岛市市立医院,青岛266071 [2]莱西市人民医院

出　　处：《现代妇产科进展》2008年第11期835-838,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨血管生成素-2(angiopoietin-2,Ang-2)和内皮抑素(endostatin,ENS)在EMs发生、发展中的作用。方法:选择25例OEMs病人作为研究组,28例同期非内膜疾病妇女作为对照组。均留取子宫内膜,使用免疫组化染色方法检测Ang-2和ENS在研究组异位、在位子宫内膜及对照组正常子宫内膜中的表达。结果:Ang-2和ENS蛋白主要定位于子宫内膜腺上皮细胞的胞浆中。Ang-2在OEMs组在位子宫内膜组织中的阳性表达率为80.00%,显著高于异位内膜(52.00%)和对照组(21.48%)(P<0.05);异位内膜组阳性表达率为52.00%,显著高于对照组(21.48%)(P<0.05);OEMs组在位内膜和对照组子宫内膜中Ang-2在分泌期(90%、30.75%)和增生期(73.33%、13.33%)的表达均无显著性差异(P>0.05);ENS在OEMs异位内膜组织中的表达为84.00%,明显高于在位内膜(56.00%)和对照组(25.00%)(P<0.05);在位内膜(56.00%)明显高于对照组(25.00%)(P<0.05)。OEMs组在位内膜中ENS分泌期的表达为50.00%,与增生期(60.00%)比较无统计学差异(P>0.05);对照组中子宫内膜ENS在分泌期的表达为23.08%,与增生期(26.67%)比较无统计学差异(P>0.05)。结论:Ang-2和ENS在子宫内膜异位症发生发展中起到重要作用。Objective： To explore the effect of Angiopoietin-2 （Ang-2） and endostatin （ENS） in genesis and development of endometriosis. Methods： Twenty-five ovarian endometrio- sis cases were enrolled into present study. 28 patients without endometriosis were selected as controls. All endometrial specimens were collected. Ang-2 and ENS were detected by immuno- histochemistry. Results：Ang-2 and ENS proteins were expressed in the cytoplasm of glandular epithelium cells. The Ang-2 positive rate was 80.00% in eutopic endometrium in the ovarian endometriosis（OEMs） ,which was significantly higher than that of ectopic endometrium in the OEMs（52.00% ） group or the control group （21.48%）（P 〈 0.05 ）. The Ang-2 positive rate was 52. 00% in ectopic endometrium in the OEMs group, which was significantly higher than that of control group （21.48%） （P 〈 0.05 ）. There was no significant difference in Ang-2 expression of OEMs group and control group between secretory endometrium and proliferative En- dometrium （P 〉 0.05 ）. The ENS positive rate was 84.00% in eetopic endometrium in the OEMs group, which was significantly higher than that of eutopic endometrium in the OEMs group（56.00% ） or the control group （ 25.00% ） （ P 〈 0.05 ）. The ENS positive rate was 56. 00% in ectopic endometrium in the OEMs group,which was significantly higher than that of control group（25.00% ）（P 〈0.05）. There was no significant difference in ENS expression of OEMs group and control group between secretory endometrium and proliferative endometrium （ P 〉 0.05 ）. Conclusion： The effects of angiopoietin-2 and endostatin in angiogenesis of endo- metriosis are important. They participate the genesis and development of endometriosis.

关 键 词：子宫内膜异位症 血管生成素-2 内皮抑素 血管生成 

分 类 号：R737.31[医药卫生—肿瘤]