非小细胞肺癌组织FGFR1OP和PTEN表达及其临床意义的研究  

Expressions of FGFR1OP and PTEN in non-small cell lung cancer tissues and their clinical significance

作　　者：谭永刚[1] 许宁[1] 张贺英[1] 

机构地区：[1]中国医科大学附属盛京医院第一肿瘤科,辽宁沈阳110004

出　　处：《中华肿瘤防治杂志》2008年第20期1561-1563,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨FGFR1OP和PTEN蛋白在非小细胞肺癌(NSCLC)中的表达情况。方法:选取58例NSCLC手术切除标本,采用SP法进行免疫组织化学染色。结果:FGFR1OP和PTEN的阳性表达率分别为91.4%(53/58)和44.8%(26/58)。FGFR1OP的表达与肿瘤的分化程度和病理类型密切相关,在鳞癌中的表达高于腺癌,P=0.002;肿瘤的分化程度较低时(腺癌P=0.003,鳞癌P=0.001)也呈现高表达。PTEN在肺腺癌中的表达高于在鳞癌中的表达,P=0.031;肿瘤低分化(腺癌P=0.023,鳞癌P=0.015)时,表达显著降低或缺失。FGFR1OP和PTEN在肺腺癌中的表达呈负相关,r=-0.733,P=0.025。结论:FGFR1OP的高表达与PTEN的低表达或表达缺失可能参与肿瘤的生长分化和进展,并提示预后不良。OBJECTIVE： To investigate the expressions of FG- FR1OP and PTEN proteins in NSCLC. METHODS： The expressions of FGFR1OP and PTEN were examined in 58 NSCLC specimens with SP method. The relationship between the expressions of those proteins and various clinicopathologic factors was evaluated. RESULTS： The positive expression rates of FGFR1OP and PTEN were 91.4%（53/58） and 44.8%（26/58）, respectively. The expression of FGFR1OP was significantly assotiated with the tumor cell differentiation and different pathological types. Higher FGFR1OP was found in squamous cell carcinomas （P = 0. 002） and lower differentiation （P= 0. 003, in adenocaicinomas; P= 0. 001, in squamous cell carcinomas）. Lower PTEN expression was correlated with poor differentiation（P =0.023, in adenocaicinomas; P=0.015, in squamous cell carcinomas） and squamous cell carcinomas （P= 0. 031）. FGFR1OP had a nagetive correlation with PTEN in adenocaicinomas, r=-0. 733, P=0. 025. CONCLUSION： High FGFRIOP expression or low PTEN expression are related to the cell differentiation and the progression of NSCLC.

关 键 词：癌 非小细胞肺 受体 成纤维细胞生长因子 肿瘤抑制蛋白质类 

分 类 号：R734.2[医药卫生—肿瘤]